Please use this identifier to cite or link to this item:
https://doi.org/10.1523/JNEUROSCI.2177-15.2016
DC Field | Value | |
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dc.title | Rich-club organization in effective connectivity among cortical neurons | |
dc.contributor.author | Nigam, S | |
dc.contributor.author | Shimono, M | |
dc.contributor.author | Ito, S | |
dc.contributor.author | Yeh, F.-C | |
dc.contributor.author | Timme, N | |
dc.contributor.author | Myroshnychenko, M | |
dc.contributor.author | Lapish, C.C | |
dc.contributor.author | Tosi, Z | |
dc.contributor.author | Hottowy, P | |
dc.contributor.author | Smith, W.C | |
dc.contributor.author | Masmanidis, S.C | |
dc.contributor.author | Litke, A.M | |
dc.contributor.author | Sporns, O | |
dc.contributor.author | Beggs, J.M | |
dc.date.accessioned | 2020-09-08T03:46:58Z | |
dc.date.available | 2020-09-08T03:46:58Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Nigam, S, Shimono, M, Ito, S, Yeh, F.-C, Timme, N, Myroshnychenko, M, Lapish, C.C, Tosi, Z, Hottowy, P, Smith, W.C, Masmanidis, S.C, Litke, A.M, Sporns, O, Beggs, J.M (2016). Rich-club organization in effective connectivity among cortical neurons. Journal of Neuroscience 36 (3) : 655-669. ScholarBank@NUS Repository. https://doi.org/10.1523/JNEUROSCI.2177-15.2016 | |
dc.identifier.issn | 0270-6474 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174630 | |
dc.description.abstract | The performance of complex networks, like the brain, depends on how effectively their elements communicate. Despite the importance of communication, it is virtually unknown how information is transferred in local cortical networks, consisting of hundreds of closely spaced neurons. To address this, it is important to record simultaneously from hundreds of neurons at a spacing that matches typical axonal connection distances, and at a temporal resolution that matches synaptic delays. We used a 512-electrode array (60_mspacing) to record spontaneous activity at 20 kHz from up to 500 neurons simultaneously in slice cultures of mouse somatosensory cortex for 1 h at a time. We applied a previously validated version of transfer entropy to quantify information transfer. Similar to in vivo reports, we found an approximately lognormal distribution of firing rates. Pairwise information transfer strengths also were nearly lognormally distributed, similar to reports of synaptic strengths. Some neurons transferred and received much more information than others, which is consistent with previous predictions. Neurons with the highest outgoing and incoming information transfer were more strongly connected to each other than chance, thus forming a “rich club.” We found similar results in networks recorded in vivo from rodent cortex, suggesting the generality of these findings. A rich-club structure has been found previously in large-scale human brain networks and is thought to facilitate communication between cortical regions. The discovery of a small, but information-rich, subset of neurons within cortical regions suggests that this population will play a vital role in communication, learning, and memory. ©2016 the authors. | |
dc.source | Unpaywall 20200831 | |
dc.subject | algorithm | |
dc.subject | Article | |
dc.subject | brain cell | |
dc.subject | craniotomy | |
dc.subject | dynamics | |
dc.subject | effective connectivity | |
dc.subject | entropy | |
dc.subject | false positive result | |
dc.subject | human | |
dc.subject | information processing | |
dc.subject | information transfer | |
dc.subject | learning | |
dc.subject | mathematical model | |
dc.subject | memory | |
dc.subject | nerve cell network | |
dc.subject | nervous system function | |
dc.subject | nonhuman | |
dc.subject | priority journal | |
dc.subject | pyramidal nerve cell | |
dc.subject | somatosensory cortex | |
dc.subject | spike | |
dc.subject | synapse | |
dc.subject | task performance | |
dc.subject | animal | |
dc.subject | C57BL mouse | |
dc.subject | cytology | |
dc.subject | mouse | |
dc.subject | nerve cell | |
dc.subject | nerve cell network | |
dc.subject | newborn | |
dc.subject | organ culture technique | |
dc.subject | physiology | |
dc.subject | Animals | |
dc.subject | Animals, Newborn | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Nerve Net | |
dc.subject | Neurons | |
dc.subject | Organ Culture Techniques | |
dc.subject | Somatosensory Cortex | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1523/JNEUROSCI.2177-15.2016 | |
dc.description.sourcetitle | Journal of Neuroscience | |
dc.description.volume | 36 | |
dc.description.issue | 3 | |
dc.description.page | 655-669 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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