Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41419-018-1081-0
DC Field | Value | |
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dc.title | Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy | |
dc.contributor.author | Hor, J.H | |
dc.contributor.author | Soh, E.S.-Y | |
dc.contributor.author | Tan, L.Y | |
dc.contributor.author | Lim, V.J.W | |
dc.contributor.author | Santosa, M.M | |
dc.contributor.author | Winanto, Institute of Molecular and Cell Biology, 61 Biopolis Drive138673, Singapore, School of Biological Science, Nanyang Technological University637551, Singapore | |
dc.contributor.author | Ho, B.X | |
dc.contributor.author | Fan, Y | |
dc.contributor.author | Soh, B.-S | |
dc.contributor.author | Ng, S.-Y | |
dc.date.accessioned | 2020-09-04T02:22:48Z | |
dc.date.available | 2020-09-04T02:22:48Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Hor, J.H, Soh, E.S.-Y, Tan, L.Y, Lim, V.J.W, Santosa, M.M, Winanto, Institute of Molecular and Cell Biology, 61 Biopolis Drive138673, Singapore, School of Biological Science, Nanyang Technological University637551, Singapore, Ho, B.X, Fan, Y, Soh, B.-S, Ng, S.-Y (2018). Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy. Cell Death and Disease 9 (11) : 1100. ScholarBank@NUS Repository. https://doi.org/10.1038/s41419-018-1081-0 | |
dc.identifier.issn | 2041-4889 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174353 | |
dc.description.abstract | Spinal Muscular Atrophy (SMA) is caused by genetic mutations in the SMN1 gene, resulting in drastically reduced levels of Survival of Motor Neuron (SMN) protein. Although SMN is ubiquitously expressed, spinal motor neurons are one of the most affected cell types. Previous studies have identified pathways uniquely activated in SMA motor neurons, including a hyperactivated ER stress pathway, neuronal hyperexcitability, and defective spliceosomes. To investigate why motor neurons are more affected than other neural types, we developed a spinal organoid model of SMA. We demonstrate overt motor neuron degeneration in SMA spinal organoids, and this degeneration can be prevented using a small molecule inhibitor of CDK4/6, indicating that spinal organoids are an ideal platform for therapeutic discovery. © 2018, The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.source | Unpaywall 20200831 | |
dc.subject | cyclin dependent kinase 4 inhibitor | |
dc.subject | cyclin dependent kinase 6 inhibitor | |
dc.subject | cyclin dependent kinase inhibitor | |
dc.subject | unclassified drug | |
dc.subject | Article | |
dc.subject | cell survival | |
dc.subject | controlled study | |
dc.subject | human | |
dc.subject | human cell | |
dc.subject | human tissue | |
dc.subject | induced pluripotent stem cell | |
dc.subject | motoneuron | |
dc.subject | nerve cell degeneration | |
dc.subject | nervous system development | |
dc.subject | neuroprotection | |
dc.subject | organoid | |
dc.subject | priority journal | |
dc.subject | spinal muscular atrophy | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.1038/s41419-018-1081-0 | |
dc.description.sourcetitle | Cell Death and Disease | |
dc.description.volume | 9 | |
dc.description.issue | 11 | |
dc.description.page | 1100 | |
Appears in Collections: | Elements Staff Publications |
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