Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-18454-z
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dc.titleEnhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification
dc.contributor.authorLim, S.H
dc.contributor.authorSun, Y
dc.contributor.authorMadanagopal Thiruvallur, T
dc.contributor.authorRosa, V
dc.contributor.authorKang, L
dc.date.accessioned2020-09-04T02:19:48Z
dc.date.available2020-09-04T02:19:48Z
dc.date.issued2018
dc.identifier.citationLim, S.H, Sun, Y, Madanagopal Thiruvallur, T, Rosa, V, Kang, L (2018). Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. Scientific Reports 8 (1) : 1596. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-18454-z
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174343
dc.description.abstractWrinkles can have a negative effect on quality of life and Botox is one of the most effective and common treatments. Argireline (Arg0), a mimetic of Botox, has been found to be safer than Botox and effective in reducing wrinkles, with efficacies up to 48% upon 4 weeks of twice daily treatment. However, the skin permeation of Arg0 is poor, due to its large molecular weight and hydrophilicity. Arg0 exists in zwitterionic form and this charged state hindered its skin permeation. Chemical modification of the peptide structure to reduce the formation of zwitterions may result in increased skin permeability. We investigated a total of 4 peptide analogues (Arg0, Arg1, Arg2, Arg3), in terms of skin permeation and wrinkle reduction. The 4 peptides were dissolved in various propylene glycol and water co-solvents. Enhanced human skin permeation was demonstrated by both Arg2 and Arg3 in vitro. On the other hand, the abilities of the 4 analogues to reduce wrinkle formation were also compared using primary human dental pulp stem cells derived neurons. By measuring the inhibition of glutamate release from the neurons in vitro, it was shown that Arg3 was the most effective, followed by Arg1, Arg0 and Arg2. © 2018 The Author(s).
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectacetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide
dc.subjectmutant protein
dc.subjectoligopeptide
dc.subjectadult
dc.subjectcell culture
dc.subjectcutaneous parameters
dc.subjectdrug effect
dc.subjectgenetics
dc.subjecthuman
dc.subjectmale
dc.subjectnerve cell
dc.subjectAdult
dc.subjectCells, Cultured
dc.subjectHumans
dc.subjectMale
dc.subjectMutant Proteins
dc.subjectNeurons
dc.subjectOligopeptides
dc.subjectSkin Aging
dc.typeArticle
dc.contributor.departmentINDUSTRY LIAISON OFFICE
dc.contributor.departmentPHARMACY
dc.contributor.departmentDENTISTRY
dc.description.doi10.1038/s41598-017-18454-z
dc.description.sourcetitleScientific Reports
dc.description.volume8
dc.description.issue1
dc.description.page1596
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