Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s13062-014-0029-2
DC Field | Value | |
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dc.title | The fundamental tradeoff in genomes and proteomes of prokaryotes established by the genetic code, codon entropy, and physics of nucleic acids and proteins | |
dc.contributor.author | Goncearenco, A | |
dc.contributor.author | Berezovsky, I.N | |
dc.date.accessioned | 2020-09-03T10:40:15Z | |
dc.date.available | 2020-09-03T10:40:15Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Goncearenco, A, Berezovsky, I.N (2014). The fundamental tradeoff in genomes and proteomes of prokaryotes established by the genetic code, codon entropy, and physics of nucleic acids and proteins. Biology direct 9 : 29. ScholarBank@NUS Repository. https://doi.org/10.1186/s13062-014-0029-2 | |
dc.identifier.issn | 17456150 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174156 | |
dc.description.abstract | BACKGROUND: Mutations in nucleotide sequences provide a foundation for genetic variability, and selection is the driving force of the evolution and molecular adaptation. Despite considerable progress in the understanding of selective forces and their compositional determinants, the very nature of underlying mutational biases remains unclear.RESULTS: We explore here a fundamental tradeoff, which analytically describes mutual adjustment of the nucleotide and amino acid compositions and its possible effect on the mutational biases. The tradeoff is determined by the interplay between the genetic code, optimization of the codon entropy, and demands on the structure and stability of nucleic acids and proteins.CONCLUSION: The tradeoff is the unifying property of all prokaryotes regardless of the differences in their phylogenies, life styles, and extreme environments. It underlies mutational biases characteristic for genomes with different nucleotide and amino acid compositions, providing foundation for evolution and adaptation. | |
dc.source | Unpaywall 20200831 | |
dc.subject | codon | |
dc.subject | proteome | |
dc.subject | archaeon | |
dc.subject | bacterium | |
dc.subject | biological model | |
dc.subject | codon | |
dc.subject | DNA base composition | |
dc.subject | entropy | |
dc.subject | genetic code | |
dc.subject | genetics | |
dc.subject | genome | |
dc.subject | mutation | |
dc.subject | Archaea | |
dc.subject | Bacteria | |
dc.subject | Base Composition | |
dc.subject | Codon | |
dc.subject | Entropy | |
dc.subject | Genetic Code | |
dc.subject | Genome | |
dc.subject | Models, Genetic | |
dc.subject | Mutation | |
dc.subject | Proteome | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1186/s13062-014-0029-2 | |
dc.description.sourcetitle | Biology direct | |
dc.description.volume | 9 | |
dc.description.page | 29 | |
Appears in Collections: | Elements Staff Publications |
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