Please use this identifier to cite or link to this item: https://doi.org/10.1111/irv.12312
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dc.titleClinical differences between respiratory viral and bacterial mono- and dual pathogen detected among Singapore military servicemen with febrile respiratory illness
dc.contributor.authorHo, Z.J.M
dc.contributor.authorZhao, X
dc.contributor.authorCook, A.R
dc.contributor.authorLoh, J.P
dc.contributor.authorNg, S.H
dc.contributor.authorTan, B.H
dc.contributor.authorLee, V.J
dc.date.accessioned2020-09-03T10:34:28Z
dc.date.available2020-09-03T10:34:28Z
dc.date.issued2015
dc.identifier.citationHo, Z.J.M, Zhao, X, Cook, A.R, Loh, J.P, Ng, S.H, Tan, B.H, Lee, V.J (2015). Clinical differences between respiratory viral and bacterial mono- and dual pathogen detected among Singapore military servicemen with febrile respiratory illness. Influenza and other Respiratory Viruses 9 (4) : 200-208. ScholarBank@NUS Repository. https://doi.org/10.1111/irv.12312
dc.identifier.issn17502640
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174124
dc.description.abstractBackground: Although it is known that febrile respiratory illnesses (FRI) may be caused by multiple respiratory pathogens, there are no population-level studies describing its impact on clinical disease. Methods: Between May 2009 and October 2012, 7733 FRI patients and controls in the Singapore military had clinical data and nasal wash samples collected prospectively and sent for PCR testing. Patients with one pathogen detected (mono-pathogen) were compared with those with two pathogens (dual pathogen) for differences in basic demographics and clinical presentation. Results: In total, 45.8% had one pathogen detected, 20.2% had two pathogens detected, 30.9% had no pathogens detected, and 3.1% had more than two pathogens. Multiple pathogens were associated with recruits, those with asthma and non-smokers. Influenza A (80.0%), influenza B (73.0%) and mycoplasma (70.6%) were most commonly associated with mono-infections, while adenovirus was most commonly associated with dual infections (62.9%). Influenza A paired with S. pneumoniae had higher proportions of chills and rigors than their respective mono-pathogens (P = 0.03, P = 0.009). H. influenzae paired with either enterovirus or parainfluenzae had higher proportions of cough with phlegm than their respective mono-pathogens. Although there were observed differences in mean proportions of body temperature, nasal symptoms, sore throat, body aches and joint pains between viral and bacterial mono-pathogens, there were few differences between distinct dual-pathogen pairs and their respective mono-pathogen counterparts. Conclusion: A substantial number of FRI patients have multiple pathogens detected. Observed clinical differences between patients of dual pathogen and mono-pathogen indicate the likely presence of complex microbial interactions between the various pathogens. © 2015 The Authors.
dc.sourceUnpaywall 20200831
dc.subjectAdenoviridae
dc.subjectadolescent
dc.subjectadult
dc.subjectarthralgia
dc.subjectArticle
dc.subjectasthma
dc.subjectbacterial infection
dc.subjectbacterium detection
dc.subjectbody temperature
dc.subjectchill
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectcoughing
dc.subjectfebrile respiratory illness
dc.subjectHaemophilus influenzae
dc.subjectheadache
dc.subjecthuman
dc.subjectInfluenza virus A
dc.subjectInfluenza virus B
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmixed infection
dc.subjectMycoplasma
dc.subjectnonhuman
dc.subjectnose smear
dc.subjectpneumonia
dc.subjectpriority journal
dc.subjectrespiratory tract disease
dc.subjectrigor
dc.subjectSingapore
dc.subjectsoldier
dc.subjectsore throat
dc.subjectStreptococcus pneumoniae
dc.subjectviral respiratory tract infection
dc.subjectvirus detection
dc.subjectBacterial Infections
dc.subjectbacterium
dc.subjectfemale
dc.subjectfever
dc.subjectgenetics
dc.subjectInfluenza, Human
dc.subjectisolation and purification
dc.subjectmicrobiology
dc.subjectmiddle aged
dc.subjectRespiratory Tract Infections
dc.subjectstatistics and numerical data
dc.subjectvirology
dc.subjectvirus
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBacteria
dc.subjectBacterial Infections
dc.subjectFemale
dc.subjectFever
dc.subjectHumans
dc.subjectInfluenza, Human
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMilitary Personnel
dc.subjectRespiratory Tract Infections
dc.subjectSingapore
dc.subjectViruses
dc.subjectYoung Adult
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1111/irv.12312
dc.description.sourcetitleInfluenza and other Respiratory Viruses
dc.description.volume9
dc.description.issue4
dc.description.page200-208
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