Please use this identifier to cite or link to this item:
https://doi.org/10.1038/srep40923
DC Field | Value | |
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dc.title | Dengue virus compartmentalization during antibody-enhanced infection | |
dc.contributor.author | Ong, E.Z | |
dc.contributor.author | Zhang, S.L | |
dc.contributor.author | Tan, H.C | |
dc.contributor.author | Gan, E.S | |
dc.contributor.author | Chan, K.R | |
dc.contributor.author | Ooi, E.E | |
dc.date.accessioned | 2020-09-02T06:38:54Z | |
dc.date.available | 2020-09-02T06:38:54Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Ong, E.Z, Zhang, S.L, Tan, H.C, Gan, E.S, Chan, K.R, Ooi, E.E (2017). Dengue virus compartmentalization during antibody-enhanced infection. Scientific Reports 7 : 40923. ScholarBank@NUS Repository. https://doi.org/10.1038/srep40923 | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/173949 | |
dc.description.abstract | Secondary infection with a heterologous dengue virus (DENV) serotype increases the risk of severe dengue, through a process termed antibody-dependent enhancement (ADE). During ADE, DENV is opsonized with non- or sub-neutralizing antibody levels that augment entry into monocytes and dendritic cells through Fc-gamma receptors (Fc3Rs). We previously reported that co-ligation of leukocyte immunoglobulin-like receptor-B1 (LILRB1) by antibody-opsonized DENV led to recruitment of SH2 domain-containing phosphatase-1 (SHP-1) to dephosphorylate spleen tyrosine kinase (Syk) and reduce interferon stimulated gene induction. Here, we show that LILRB1 also signals through SHP-1 to attenuate the otherwise rapid acidification for lysosomal enzyme activation following Fc 3R-mediated uptake of DENV. Reduced or slower trafficking of antibody-opsonized DENV to lytic phagolysosomal compartments, demonstrates how co-ligation of LILRB1 also permits DENV to overcome a cell-autonomous immune response, enhancing intracellular survival of DENV. Our findings provide insights on how antiviral drugs that modify phagosome acidification should be used for viruses such as DENV. © The Author(s) 2017. | |
dc.source | Unpaywall 20200831 | |
dc.subject | leukocyte antigen | |
dc.subject | leukocyte immunoglobulin like receptor subfamily B member 1 | |
dc.subject | LILRB1 protein, human | |
dc.subject | protein tyrosine phosphatase SHP 1 | |
dc.subject | PTPN6 protein, human | |
dc.subject | antibody dependent enhancement | |
dc.subject | dengue | |
dc.subject | Dengue virus | |
dc.subject | human | |
dc.subject | immunology | |
dc.subject | metabolism | |
dc.subject | phagosome | |
dc.subject | physiology | |
dc.subject | tumor cell line | |
dc.subject | virus entry | |
dc.subject | Antibody-Dependent Enhancement | |
dc.subject | Antigens, CD | |
dc.subject | Cell Line, Tumor | |
dc.subject | Dengue | |
dc.subject | Dengue Virus | |
dc.subject | Humans | |
dc.subject | Leukocyte Immunoglobulin-like Receptor B1 | |
dc.subject | Phagosomes | |
dc.subject | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | |
dc.subject | Virus Internalization | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1038/srep40923 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 7 | |
dc.description.page | 40923 | |
Appears in Collections: | Elements Staff Publications |
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