Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.8748
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dc.titleXAF1 promotes neuroblastoma tumor suppression and is required for KIF1B?-mediated apoptosis
dc.contributor.authorChoo, Z
dc.contributor.authorKoh, R.Y.L
dc.contributor.authorWallis, K
dc.contributor.authorKoh, T.J.W
dc.contributor.authorKuick, C.H
dc.contributor.authorSobrado, V
dc.contributor.authorKenchappa, R.S
dc.contributor.authorLoh, A.H.P
dc.contributor.authorSoh, S.Y
dc.contributor.authorSchlisio, S
dc.contributor.authorChang, K.T.E
dc.contributor.authorChen, Z.X
dc.date.accessioned2020-09-01T01:03:37Z
dc.date.available2020-09-01T01:03:37Z
dc.date.issued2016
dc.identifier.citationChoo, Z, Koh, R.Y.L, Wallis, K, Koh, T.J.W, Kuick, C.H, Sobrado, V, Kenchappa, R.S, Loh, A.H.P, Soh, S.Y, Schlisio, S, Chang, K.T.E, Chen, Z.X (2016). XAF1 promotes neuroblastoma tumor suppression and is required for KIF1B?-mediated apoptosis. Oncotarget 7 (23) : 34229-34239. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.8748
dc.identifier.issn19492553
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/173827
dc.description.abstractNeuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system. Current treatment modalities do not fully exploit the genetic basis between the different molecular subtypes and little is known about the targets discovered in recent mutational and genetic studies. Neuroblastomas with poor prognosis are often characterized by 1p36 deletion, containing the kinesin gene KIF1B. Its beta isoform, KIF1B?, is required for NGF withdrawal-dependent apoptosis, mediated by the induction of XIAP-associated Factor 1 (XAF1). Here, we showed that XAF1 low expression correlates with poor survival and disease status. KIF1B? deletion results in loss of XAF1 expression, suggesting that XAF1 is indeed a downstream target of KIF1B?. XAF1 silencing protects from NGF withdrawal and from KIF1B?-mediated apoptosis. Overexpression of XAF1 impairs tumor progression whereas knockdown of XAF1 promotes tumor growth, suggesting that XAF1 may be a candidate tumor suppressor in neuroblastoma and its associated pathway may be important for developing future interventions.
dc.sourceUnpaywall 20200831
dc.subjectcaspase 3
dc.subjectcell protein
dc.subjectkinesin
dc.subjectprotein KIF1B beta
dc.subjectshort hairpin RNA
dc.subjectunclassified drug
dc.subjectXIAP associated factor 1
dc.subjectF box protein
dc.subjectKIF1B protein, human
dc.subjectKif1b protein, mouse
dc.subjectkinesin
dc.subjectsignal peptide
dc.subjecttumor marker
dc.subjecttumor protein
dc.subjecttumor suppressor protein
dc.subjectXAF1 protein, human
dc.subjectXAF1 protein, mouse
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectArticle
dc.subjectbioinformatics
dc.subjectcancer inhibition
dc.subjectcancer prognosis
dc.subjectcancer survival
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectdisease status
dc.subjectfemale
dc.subjectgene silencing
dc.subjectgeneral aspects of disease
dc.subjectgenetic transfection
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectknockout mouse
dc.subjectmajor clinical study
dc.subjectmolecular dynamics
dc.subjectmouse
dc.subjectneuroblastoma
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectoverall survival
dc.subjectprotein analysis
dc.subjectprotein cleavage
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectsurvival rate
dc.subjectsurvival time
dc.subjecttumor growth
dc.subjecttumor volume
dc.subjectanimal
dc.subjectapoptosis
dc.subjectgene expression regulation
dc.subjectKaplan Meier method
dc.subjectmetabolism
dc.subjectmortality
dc.subjectneuroblastoma
dc.subjectpathology
dc.subjectphysiology
dc.subjectprognosis
dc.subjecttumor cell line
dc.subjectxenograft
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectBiomarkers, Tumor
dc.subjectCell Line, Tumor
dc.subjectF-Box Proteins
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectHeterografts
dc.subjectHumans
dc.subjectIntracellular Signaling Peptides and Proteins
dc.subjectKaplan-Meier Estimate
dc.subjectKinesin
dc.subjectMice
dc.subjectMice, Knockout
dc.subjectNeoplasm Proteins
dc.subjectNeuroblastoma
dc.subjectPrognosis
dc.subjectTumor Suppressor Proteins
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.18632/oncotarget.8748
dc.description.sourcetitleOncotarget
dc.description.volume7
dc.description.issue23
dc.description.page34229-34239
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