Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2018.12.005
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dc.titleThe longitudinal decline of white matter microstructural integrity in behavioral variant frontotemporal dementia and its association with executive function
dc.contributor.authorYU JUNHONG
dc.contributor.authorLee, Tatia MC
dc.date.accessioned2020-08-31T01:30:11Z
dc.date.available2020-08-31T01:30:11Z
dc.date.issued2019-04-01
dc.identifier.citationYU JUNHONG, Lee, Tatia MC (2019-04-01). The longitudinal decline of white matter microstructural integrity in behavioral variant frontotemporal dementia and its association with executive function. NEUROBIOLOGY OF AGING 76 : 62-70. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2018.12.005
dc.identifier.issn0197-4580
dc.identifier.issn1558-1497
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/173628
dc.description.abstractThe longitudinal decline in the integrity of several white matter (WM) tracts in behavioral variant frontotemporal dementia (bvFTD) has been documented. However, there is yet a clear relationship between this decline and that of executive function (EF), for the WM changes to meaningfully track progression in bvFTD. We sought to validate the use of diffusion tensor imaging (DTI) in tracking the progression of bvFTD with its associated decline in EF. Baseline and 1-year follow-up DTI scans were acquired from 23 patients with bvFTD and 26 healthy controls. EF composite score was derived via multiple tests. The longitudinal changes in DTI metrics were examined in both groups. Then, among patients (N = 18), we examined the associations between these changes and that of EF. Widespread WM alterations and decline in EF were observed only in patients. This EF decline was mostly associated with the disrupted integrity of the corpus callosum and anterior corona radiata. These longitudinal findings support the use of DTI in tracking the progression of bvFTD and its associated EF decline.
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectGeriatrics & Gerontology
dc.subjectNeurosciences
dc.subjectNeurosciences & Neurology
dc.subjectFrontotemporal dementia
dc.subjectExecutive function
dc.subjectDTI
dc.subjectWhite matter
dc.subjectCorpus callosum
dc.subjectLOBAR DEGENERATION
dc.subjectNEUROPATHOLOGY
dc.subjectABNORMALITIES
dc.subjectCRITERIA
dc.subjectATROPHY
dc.subjectBRAIN
dc.typeArticle
dc.date.updated2020-08-28T07:50:29Z
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.description.doi10.1016/j.neurobiolaging.2018.12.005
dc.description.sourcetitleNEUROBIOLOGY OF AGING
dc.description.volume76
dc.description.page62-70
dc.published.statePublished
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