Please use this identifier to cite or link to this item: https://doi.org/10.1099/vir.0.055277-0
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dc.titleDengue virus-infected human monocytes trigger late activation of caspase-1, which mediates pro-inflammatory IL-1 beta secretion and pyroptosis
dc.contributor.authorTan, Ter Yong
dc.contributor.authorChu, Justin Jang Hann
dc.date.accessioned2020-08-21T08:05:18Z
dc.date.available2020-08-21T08:05:18Z
dc.date.issued2013-10
dc.identifier.citationTan, Ter Yong, Chu, Justin Jang Hann (2013-10). Dengue virus-infected human monocytes trigger late activation of caspase-1, which mediates pro-inflammatory IL-1 beta secretion and pyroptosis. JOURNAL OF GENERAL VIROLOGY 94 (PART10) : 2215-2220. ScholarBank@NUS Repository. https://doi.org/10.1099/vir.0.055277-0
dc.identifier.issn00221317
dc.identifier.issn14652099
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/173290
dc.description.abstractDengue virus (DENV) infection affects millions of people annually and has the potential to cause fatal haemorrhagic fever and shock. Although the underlying pathogenesis of severe dengue illness is still unclear, current evidence suggests that severe disease progression has an immunological basis. In this study, we investigated the role of caspase-1 during host-pathogen interactions within DENV-infected human monocytes. Using DENV-infected primary monocytes, we examined caspase-1 at various levels of gene expression and probed for potential immune consequences mediated by caspase-1 such as secretion of pro-inflammatory IL-1β and pyroptotic cell death. We report that DENV-infected monocytes upregulated functional caspase-1 mRNA and pro-caspase-1 activation as a late response to infection. In addition, we found that caspase-1 is responsible for IL-1β secretion and pyroptosis of DENV-infected monocytes. Together, our results show that late caspase-1 activation within DENV-infected monocytes can contribute to pro-inflammatory outcomes that might play a role in dengue immunopathogenesis. © 2013 SGM.
dc.language.isoen
dc.publisherMicrobiology Society
dc.sourceElements
dc.subjectApoptosis
dc.subjectCaspase 1
dc.subjectCells, Cultured
dc.subjectGene Expression Regulation
dc.subjectHumans
dc.subjectInflammation
dc.subjectInterleukin-1beta
dc.subjectMonocytes
dc.subjectTime Factors
dc.subjectTranscriptome
dc.typeArticle
dc.date.updated2020-06-23T09:10:46Z
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.description.doi10.1099/vir.0.055277-0
dc.description.sourcetitleJOURNAL OF GENERAL VIROLOGY
dc.description.volume94
dc.description.issuePART10
dc.description.page2215-2220
dc.description.placeUNITED KINGDOM
dc.published.statePublished
dc.description.redepositCompleted
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