Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.antiviral.2017.11.017
DC Field | Value | |
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dc.title | An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease | |
dc.contributor.author | Tan, Yong Wah | |
dc.contributor.author | Yam, Wan Keat | |
dc.contributor.author | Sun, Jialei | |
dc.contributor.author | Chu, Justin Jang Hann | |
dc.date.accessioned | 2020-08-21T06:05:39Z | |
dc.date.available | 2020-08-21T06:05:39Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier.citation | Tan, Yong Wah, Yam, Wan Keat, Sun, Jialei, Chu, Justin Jang Hann (2018-01-01). An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease. ANTIVIRAL RESEARCH 149 : 143-149. ScholarBank@NUS Repository. https://doi.org/10.1016/j.antiviral.2017.11.017 | |
dc.identifier.issn | 01663542 | |
dc.identifier.issn | 18729096 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/173279 | |
dc.description.abstract | © 2017 Elsevier B.V. A common childhood affliction of viral origin in young children and immunocompromised adults, the Hand, Foot and Mouth Disease (HFMD) has become a significant public health concern in the Asia-Pacific Region. Characterized by the appearance of vesiculopapular rashes on the hands, feet and mouth, the disease is generally mild and self-limiting. In a minority of cases, patients can develop neurological complications that could result in permanent morbidity or even fatality. In the absence of a specific antiviral for treatment, medical care is limited to supportive and symptomatic relief, presenting a need for more research into an effective antiviral to be used in the management of the disease. In this study, we evaluated the efficacy of chloroquine, a FDA-approved lysosomotropic agent, against several serotypes of HFMD-associated enteroviruses, including EV-A71, in reducing infectious virus production. We have also evaluated chloroquine in a murine model of EV-A71 infection to ascertain its antiviral efficacy in vivo. The results suggest that chloroquine could be a broad-acting antiviral effective against HFMD-associated enteroviruses. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Pharmacology & Pharmacy | |
dc.subject | Virology | |
dc.subject | Enterovirus | |
dc.subject | EV-A71 | |
dc.subject | Chloroquine | |
dc.subject | HFMD | |
dc.subject | Antiviral | |
dc.subject | ENTEROVIRUS 71 | |
dc.subject | CHINA | |
dc.subject | EPIDEMIOLOGY | |
dc.subject | CHILDREN | |
dc.subject | SINGAPORE | |
dc.subject | PROTEIN | |
dc.subject | MALARIA | |
dc.type | Article | |
dc.date.updated | 2020-06-23T07:54:37Z | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1016/j.antiviral.2017.11.017 | |
dc.description.sourcetitle | ANTIVIRAL RESEARCH | |
dc.description.volume | 149 | |
dc.description.page | 143-149 | |
dc.published.state | Published | |
dc.description.redeposit | completed | |
Appears in Collections: | Staff Publications Elements |
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