1. ScholarBank@NUS
  2. 1. Staff
  3. Staff Publications
Please use this identifier to cite or link to this item: https://doi.org/10.1007/978-1-4939-7592-1_11
DC FieldValue
dc.titleSphingolipid Analysis in Clinical Research
dc.contributor.authorBurla, B
dc.contributor.authorMuralidharan, S
dc.contributor.authorWenk, MR
dc.contributor.authorTorta, F
dc.date.accessioned2020-08-21T05:59:58Z
dc.date.available2020-08-21T05:59:58Z
dc.date.issued2018-01-01
dc.identifier.citationBurla, B, Muralidharan, S, Wenk, MR, Torta, F (2018-01-01). Sphingolipid Analysis in Clinical Research. Methods Mol Biol 1730 : 135-162. ScholarBank@NUS Repository. https://doi.org/10.1007/978-1-4939-7592-1_11
dc.identifier.issn10643745
dc.identifier.issn19406029
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/173274
dc.description.abstract© Springer Science+Business Media, LLC 2018. Sphingolipids are the most diverse class of lipids due to the numerous variations in their structural components. This diversity is also reflected in their extremely different functions. Sphingolipids are not only constituents of cell membranes but have also emerged as key signaling molecules involved in a variety of cellular functions, such as cell growth and differentiation, proliferation, and apoptotic cell death. Lipidomic analyses in clinical research have identified pathways and products of sphingolipid metabolism that are altered in several human pathologies. In this article, we describe how to properly design a lipidomic experiment in clinical research, how to handle plasma and serum samples for this purpose, and how to measure sphingolipids using liquid chromatography-mass spectrometry.
dc.publisherSpringer New York
dc.sourceElements
dc.subjectCeramide
dc.subjectClinical mass spectrometry
dc.subjectGlucosylceramide
dc.subjectLipidomics
dc.subjectMass spectrometry
dc.subjectQuality control
dc.subjectSphingolipidomics
dc.subjectSphingolipids
dc.subjectSphingomyelin
dc.subjectSphingosine-1-phosphate
dc.subjectBlood Specimen Collection
dc.subjectChromatography, Liquid
dc.subjectHumans
dc.subjectMass Spectrometry
dc.subjectMetabolomics
dc.subjectResearch Design
dc.subjectSphingolipids
dc.typeArticle
dc.date.updated2020-06-17T04:59:58Z
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentMEDICINE
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1007/978-1-4939-7592-1_11
dc.description.sourcetitleMethods Mol Biol
dc.description.volume1730
dc.description.page135-162
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
65. Sphingolipid Analysis in Clinical Research.pdfPublished version286.81 kBAdobe PDF

CLOSED

None

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.