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Title: Risk estimation in retrospective studies
Authors: WEI XING
Keywords: risk, case-control study, odds ratio, prevalence, Bayes' theorem
Issue Date: 23-Nov-2009
Citation: WEI XING (2009-11-23). Risk estimation in retrospective studies. ScholarBank@NUS Repository.
Abstract: The analysis of data arising from retrospective studies traditionally followed methods
involving estimation of relative risks and/or odds ratios. Little attention was given to
estimation of risks, presumably due to constraint of such experimental designs, as well
as the ease of modelling of odds ratio by logistic regression. Here we present some
results for the estimation of risks in a general 2 by k contingency table setting, for a
dichotomous outcome variable and under some reasonable assumption of prevalence.
We also examine the properties of proposed estimators, and apply them to a largescale
genome-wide association (GWA) study data to demonstrate some relevance of the
Appears in Collections:Master's Theses (Open)

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