Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.201700548
Title: A Highly Efficient and Photostable Photosensitizer with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Anticancer Therapy
Authors: Wu, Wenbo
Mao, Duo 
Hu, Fang 
Xu, Shidang 
Chen, Chao
Zhang, Chong-Jing 
Cheng, Xiamin
Yuan, Youyong 
Ding, Dan 
Kong, Deling
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
aggregation-induced emission
near-infrared emission
photo-dynamictherapy
photosensitizers
singlet oxygen
LIGHT-UP PROBE
NANOPARTICLES
AIE
DERIVATIVES
GRAPHENE
CELLS
Issue Date: 6-Sep-2017
Publisher: WILEY-V C H VERLAG GMBH
Citation: Wu, Wenbo, Mao, Duo, Hu, Fang, Xu, Shidang, Chen, Chao, Zhang, Chong-Jing, Cheng, Xiamin, Yuan, Youyong, Ding, Dan, Kong, Deling, Liu, Bin (2017-09-06). A Highly Efficient and Photostable Photosensitizer with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Anticancer Therapy. ADVANCED MATERIALS 29 (33). ScholarBank@NUS Repository. https://doi.org/10.1002/adma.201700548
Abstract: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Photodynamic therapy (PDT), which relies on photosensitizers (PS) and light to generate reactive oxygen species to kill cancer cells or bacteria, has attracted much attention in recent years. PSs with both bright emission and efficient singlet oxygen generation have also been used for image-guided PDT. However, simultaneously achieving effective 1O2 generation, long wavelength absorption, and stable near-infrared (NIR) emission with low dark toxicity in a single PS remains challenging. In addition, it is well known that when traditional PSs are made into nanoparticles, they encounter quenched fluorescence and reduced 1O2 production. In this contribution, these challenging issues have been successfully addressed through designing the first photostable photosensitizer with aggregation-induced NIR emission and very effective 1O2 generation in aggregate state. The yielded nanoparticles show very effective 1O2 generation, bright NIR fluorescence centered at 820 nm, excellent photostability, good biocompatibility, and negligible dark in vivo toxicity. Both in vitro and in vivo experiments prove that the nanoparticles are excellent candidates for image-guided photodynamic anticancer therapy.
Source Title: ADVANCED MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/170649
ISSN: 0935-9648
1521-4095
DOI: 10.1002/adma.201700548
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