Please use this identifier to cite or link to this item: https://doi.org/10.1039/c8qm00383a
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dc.titleAIEgen bioconjugates for specific detection of disease-related protein biomarkers
dc.contributor.authorCHONG KOK CHAN
dc.contributor.authorHu, F
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-16T04:57:42Z
dc.date.available2020-06-16T04:57:42Z
dc.date.issued2019-01-01
dc.identifier.citationCHONG KOK CHAN, Hu, F, LIU BIN (2019-01-01). AIEgen bioconjugates for specific detection of disease-related protein biomarkers. Materials Chemistry Frontiers 3 (1) : 12-24. ScholarBank@NUS Repository. https://doi.org/10.1039/c8qm00383a
dc.identifier.issn2052-1537
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169804
dc.description.abstractMis-regulation of certain proteins and enzymes is often identified as an indicator of many pathologies, and these disease-related proteins can be used as biomarkers to diagnose disease onset and progression. Indeed, bioprobes with various working mechanisms have been developed for the sensing of these protein biomarkers. Particularly, fluorophore-based probes have favorably been welcomed due to their outstanding properties such as easy synthesis, facile modification, real-time, on-site responsiveness, and noninvasiveness. However, conventional fluorophores usually suffer from aggregation-caused quenching, which greatly affects their sensitivity and photostability. To overcome this challenge, fluorogens with aggregation-induced emission features have been developed, which offer higher signal to noise ratios and better resistance to photobleaching in sensing and imaging. In this review, the recent development of specific light-up bioprobes based on AIEgen bioconjugates for sensing and imaging of disease-related protein biomarkers is summarized and discussed with the aim to serve as a guidance for the design of state-of-the-art AIEgen probes for a wide range of biomedical applications.
dc.publisherRoyal Society of Chemistry (RSC)
dc.sourceElements
dc.typeReview
dc.date.updated2020-06-13T14:52:40Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1039/c8qm00383a
dc.description.sourcetitleMaterials Chemistry Frontiers
dc.description.volume3
dc.description.issue1
dc.description.page12-24
dc.published.statePublished
dc.grant.idR279-000-444-281
dc.grant.idR279-000-483-281
dc.grant.idR279-000-482-133
dc.grant.fundingagencyNational Research Foundation Singapore
dc.grant.fundingagencyNational University of Singapore
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