Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0229665
DC FieldValue
dc.titleHypertension, blood pressure control and diabetic retinopathy in a large populationbased study
dc.contributor.authorLiu, L
dc.contributor.authorQuang, ND
dc.contributor.authorBanu, R
dc.contributor.authorKumar, H
dc.contributor.authorTham, YC
dc.contributor.authorCheng, CY
dc.contributor.authorWong, TY
dc.contributor.authorSabanayagam, C
dc.date.accessioned2020-06-04T02:49:38Z
dc.date.available2020-06-04T02:49:38Z
dc.date.issued2020-01-01
dc.identifier.citationLiu, L, Quang, ND, Banu, R, Kumar, H, Tham, YC, Cheng, CY, Wong, TY, Sabanayagam, C (2020-01-01). Hypertension, blood pressure control and diabetic retinopathy in a large populationbased study. PLoS ONE 15 (3) : e0229665-. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0229665
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169197
dc.description.abstract© 2020 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Clinical trials have shown beneficial effects of blood pressure (BP) control in reducing the risk of diabetic retinopathy (DR). However, association between BP control and DR in population- based studies is not clear. We aimed to examine the association of hypertension and BP control with DR. Methods: We analysed data from a population-based cross-sectional study of Chinese, Malay and Indians adults with diabetes and hypertension (2004-2011, n = 2189, aged 40-80 years) in Singapore. DR severity was assessed from retinal photographs and graded for any- and vision-threatening DR (VTDR) using the modified Airlie House classification. Hypertension status was classified into (1) good control: on treatment (SBP < 130 and DBP < 80 mm Hg), (2) moderate control: on treatment, with BP levels other than group 1 and 3, (3) poor control: on treatment (SBP ≥140 and DBP ≥ 90 mm Hg), (4) untreated hypertension, any BP level. SBP, DBP and pulse pressure (PP) were analyzed as categories and as continuous variables. The association between BP and DR was assessed using multivariable logistic regression models. Results: The prevalence of any-DR and VTDR in the study population was 33.8% and 9.0% respectively. Both poorly controlled and untreated hypertension were significantly associated with any-DR with odds ratio (OR) (95% confidence interval [CI]) of 1.97 (1.39-2.83), and 2.01 [1.34-3.05]. Among BP components, SBP and PP were associated with both any-DR and VTDR with OR (95% CI) of 1.45 (1.28-1.65) and 1.61 (1.41-1.84) for any-DR, and 1.44 (1.19-1.76) and 1.67 (1.37-2.06) for VTDR. Conclusion: In a population-based sample of Asian adults with diabetes and hypertension, treated but poorly controlled as well as untreated hypertension were significantly associated with any- DR. Among the BP components, higher SBP and PP levels were associated with both any- DR and VTDR. Further longitudinal studies are necessary to confirm our findings.
dc.publisherPublic Library of Science (PLoS)
dc.sourceElements
dc.typeArticle
dc.date.updated2020-06-03T13:12:47Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pone.0229665
dc.description.sourcetitlePLoS ONE
dc.description.volume15
dc.description.issue3
dc.description.pagee0229665-
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
BP control and DR_PLoS One Mar 10 2020.pdfPublished version912.65 kBAdobe PDF

OPEN

PublishedView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.