Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.tim.2015.12.004
DC Field | Value | |
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dc.title | The Interplay of Dengue Virus Morphological Diversity and Human Antibodies | |
dc.contributor.author | LOK SHEE MEI | |
dc.date.accessioned | 2020-05-27T06:58:15Z | |
dc.date.available | 2020-05-27T06:58:15Z | |
dc.date.issued | 2016-04-24 | |
dc.identifier.citation | LOK SHEE MEI (2016-04-24). The Interplay of Dengue Virus Morphological Diversity and Human Antibodies. Trends in Microbiology 24 (4) : 284-293. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tim.2015.12.004 | |
dc.identifier.issn | 0966-842X | |
dc.identifier.issn | 1878-4380 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/168491 | |
dc.description.abstract | Dengue virus (DENV) infects ∼400 million people annually, and there is no available vaccine or therapeutics. It is not clear why candidate vaccines provide only modest protection. In addition to the presence of four different dengue serotypes, there is also structural heterogeneity in DENV infectious particles, even within a strain. This severely complicates the development of vaccines and therapeutics. The currently known different morphologies of DENV are: immature, partially mature, compact mature, and expanded mature forms of the virus. In this review I describe these forms of the virus, their infectivity, and how antibodies could recognize these morphologies. I also discuss possible vaccine and antibody therapeutic formulations to protect against all morphologies. | |
dc.description.uri | https://www-sciencedirect-com.libproxy1.nus.edu.sg/science/article/pii/S0966842X15002802?via%3Dihub | |
dc.language.iso | en | |
dc.publisher | Trends in Microbiology | |
dc.subject | Antibodies | |
dc.subject | Dengue Virus | |
dc.subject | Morphologies | |
dc.subject | Therapeutics | |
dc.subject | Vaccines | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1016/j.tim.2015.12.004 | |
dc.description.sourcetitle | Trends in Microbiology | |
dc.description.volume | 24 | |
dc.description.issue | 4 | |
dc.description.page | 284-293 | |
dc.published.state | Published | |
dc.grant.id | MOE2012-T3-1-008 | |
dc.grant.fundingagency | Singapore Ministry of Education | |
dc.relation.dataset | 10.1016/j.tim.2015.12.004 | |
Appears in Collections: | Staff Publications Elements |
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The interplay of dengue virus morphological diversity and human antibodies.pdf | 3.65 MB | Adobe PDF | CLOSED | Published |
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