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https://scholarbank.nus.edu.sg/handle/10635/166348
| Title: | BNIP-2 ACTIVATION OF FORCE DRIVES YAP CYTOSOLIC RETENTION FOR CARDIOMYOCYTE DIFFERENTIATION | Authors: | WONG CHEN PEI DARREN | ORCID iD: |  orcid.org/0000-0002-1627-5792 |
Keywords: | BNIP-2, cardiomyocyte, LATS, YAP, force, RhoA | Issue Date: | 31-Oct-2019 | Citation: | WONG CHEN PEI DARREN (2019-10-31). BNIP-2 ACTIVATION OF FORCE DRIVES YAP CYTOSOLIC RETENTION FOR CARDIOMYOCYTE DIFFERENTIATION. ScholarBank@NUS Repository. | Abstract: | BNIP-2 is a BCH domain containing protein that was identified in this thesis to bind LATS-1 kinase and regulate cardiomyocyte differentiation. This interaction was required to down regulate downstream YAP target gene expression during differentiation. Furthermore, BNIP-2 regulation of cellular contractility was required for BNIP-2, LATS and also LATS, YAP interaction. | URI: | https://scholarbank.nus.edu.sg/handle/10635/166348 |
| Appears in Collections: | Ph.D Theses (Open) |
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| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| A0067081H Phd Thesis .pdf | 18.19 MB | Adobe PDF | OPEN | None | View/Download |
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