Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0075560
DC Field | Value | |
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dc.title | Bofu-Tsu-Shosan, an Oriental Herbal Medicine, Exerts a Combinatorial Favorable Metabolic Modulation Including Antihypertensive Effect on a Mouse Model of Human Metabolic Disorders with Visceral Obesity | |
dc.contributor.author | Azushima K. | |
dc.contributor.author | Tamura K. | |
dc.contributor.author | Wakui H. | |
dc.contributor.author | Maeda A. | |
dc.contributor.author | Ohsawa M. | |
dc.contributor.author | Uneda K. | |
dc.contributor.author | Kobayashi R. | |
dc.contributor.author | Kanaoka T. | |
dc.contributor.author | Dejima T. | |
dc.contributor.author | Fujikawa T. | |
dc.contributor.author | Yamashita A. | |
dc.contributor.author | Toya Y. | |
dc.contributor.author | Umemura S. | |
dc.date.accessioned | 2020-03-31T03:00:43Z | |
dc.date.available | 2020-03-31T03:00:43Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Azushima K., Tamura K., Wakui H., Maeda A., Ohsawa M., Uneda K., Kobayashi R., Kanaoka T., Dejima T., Fujikawa T., Yamashita A., Toya Y., Umemura S. (2013). Bofu-Tsu-Shosan, an Oriental Herbal Medicine, Exerts a Combinatorial Favorable Metabolic Modulation Including Antihypertensive Effect on a Mouse Model of Human Metabolic Disorders with Visceral Obesity. PLoS ONE 8 (10) : e75560. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0075560 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/166190 | |
dc.description.abstract | Accumulating evidence indicates that metabolic dysfunction with visceral obesity is a major medical problem associated with the development of hypertension, type 2 diabetes (T2DM) and dyslipidemia, and ultimately severe cardiovascular and renal disease. Therefore, an effective anti-obesity treatment with a concomitant improvement in metabolic profile is important for the treatment of metabolic dysfunction with visceral obesity. Bofu-tsu-shosan (BOF) is one of oriental herbal medicine and is clinically available to treat obesity in Japan. Although BOF is a candidate as a novel therapeutic strategy to improve metabolic dysfunction with obesity, the mechanism of its beneficial effect is not fully elucidated. Here, we investigated mechanism of therapeutic effects of BOF on KKAy mice, a model of human metabolic disorders with obesity. Chronic treatment of KKAy mice with BOF persistently decreased food intake, body weight gain, low-density lipoprotein cholesterol and systolic blood pressure. In addition, both tissue weight and cell size of white adipose tissue (WAT) were decreased, with concomitant increases in the expression of adiponectin and peroxisome proliferator-activated receptors genes in WAT as well as the circulating adiponectin level by BOF treatment. Furthermore, gene expression of uncoupling protein-1, a thermogenesis factor, in brown adipose tissue and rectal temperature were both elevated by BOF. Intriguingly, plasma acylated-ghrelin, an active form of orexigenic hormone, and short-term food intake were significantly decreased by single bolus administration of BOF. These results indicate that BOF exerts a combinatorial favorable metabolic modulation including antihypertensive effect, at least partially, via its beneficial effect on adipose tissue function and its appetite-inhibitory property through suppression on the ghrelin system. © 2013 Azushima et al. | |
dc.publisher | Public Library of Science | |
dc.source | Unpaywall 20200320 | |
dc.subject | adiponectin | |
dc.subject | bofu tsu shosan | |
dc.subject | ghrelin | |
dc.subject | herbaceous agent | |
dc.subject | low density lipoprotein cholesterol | |
dc.subject | peroxisome proliferator activated receptor alpha | |
dc.subject | peroxisome proliferator activated receptor gamma | |
dc.subject | plasma acylated ghrelin | |
dc.subject | unclassified drug | |
dc.subject | uncoupling protein 1 | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | animal tissue | |
dc.subject | antihypertensive activity | |
dc.subject | article | |
dc.subject | brown adipose tissue | |
dc.subject | cell size | |
dc.subject | cholesterol blood level | |
dc.subject | controlled study | |
dc.subject | drug mechanism | |
dc.subject | food intake | |
dc.subject | gene expression | |
dc.subject | heart rate | |
dc.subject | herbal medicine | |
dc.subject | hypertension | |
dc.subject | intraabdominal fat | |
dc.subject | long term care | |
dc.subject | male | |
dc.subject | metabolic disorder | |
dc.subject | mouse | |
dc.subject | non insulin dependent diabetes mellitus | |
dc.subject | nonhuman | |
dc.subject | obesity | |
dc.subject | protein blood level | |
dc.subject | rectum temperature | |
dc.subject | systolic blood pressure | |
dc.subject | tissues | |
dc.subject | visceral obesity | |
dc.subject | weight gain | |
dc.subject | white adipose tissue | |
dc.subject | Animals | |
dc.subject | Blood Pressure | |
dc.subject | Disease Models, Animal | |
dc.subject | Drugs, Chinese Herbal | |
dc.subject | Herbal Medicine | |
dc.subject | Humans | |
dc.subject | Ion Channels | |
dc.subject | Metabolic Diseases | |
dc.subject | Mice | |
dc.subject | Mitochondrial Proteins | |
dc.subject | Obesity, Abdominal | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1371/journal.pone.0075560 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 8 | |
dc.description.issue | 10 | |
dc.description.page | e75560 | |
Appears in Collections: | Staff Publications Elements |
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