Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0085616
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dc.titleLittle evidence of avian or equine influenza virus infection among a cohort of Mongolian adults with animal exposures, 2010-2011
dc.contributor.authorKhurelbaatar N.
dc.contributor.authorKrueger W.S.
dc.contributor.authorHeil G.L.
dc.contributor.authorDarmaa B.
dc.contributor.authorUlziimaa D.
dc.contributor.authorTserennorov D.
dc.contributor.authorBaterdene A.
dc.contributor.authorAnderson B.D.
dc.contributor.authorGray G.C.
dc.date.accessioned2020-03-26T06:44:40Z
dc.date.available2020-03-26T06:44:40Z
dc.date.issued2014
dc.identifier.citationKhurelbaatar N., Krueger W.S., Heil G.L., Darmaa B., Ulziimaa D., Tserennorov D., Baterdene A., Anderson B.D., Gray G.C. (2014). Little evidence of avian or equine influenza virus infection among a cohort of Mongolian adults with animal exposures, 2010-2011. PLoS ONE 9 (1) : e85616. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0085616
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/165963
dc.description.abstractAvian (AIV) and equine influenza virus (EIV) have been repeatedly shown to circulate among Mongolia's migrating birds or domestic horses. In 2009, 439 Mongolian adults, many with occupational exposure to animals, were enrolled in a prospective cohort study of zoonotic influenza transmission. Sera were drawn upon enrollment and again at 12 and 24 months. Participants were contacted monthly for 24 months and queried regarding episodes of acute influenza-like illnesses (ILI). Cohort members confirmed to have acute influenza A infections, permitted respiratory swab collections which were studied with rRT-PCR for influenza A. Serologic assays were performed against equine, avian, and human influenza viruses. Over the 2 yrs of follow-up, 100 ILI investigations in the cohort were conducted. Thirty-six ILI cases (36%) were identified as influenza A infections by rRT-PCR; none yielded evidence for AIV or EIV. Serological examination of 12 mo and 24 mo annual sera revealed 37 participants had detectable antibody titers (?1:10) against studied viruses during the course of study follow-up: 21 against A/Equine/Mongolia/01/2008(H3N8); 4 against an avian A/Teal/Hong Kong/w3129(H6N1), 11 against an avian-like A/Hong Kong/1073/1999(H9N2), and 1 against an avian A/Migrating duck/Hong Kong/MPD268/2007(H10N4) virus. However, all such titers were <1:80 and none were statistically associated with avian or horse exposures. A number of subjects had evidence of seroconversion to zoonotic viruses, but the 4-fold titer changes were again not associated with avian or horse exposures. As elevated antibodies against seasonal influenza viruses were high during the study period, it seems likely that cross-reacting antibodies against seasonal human influenza viruses were a cause of the low-level seroreactivity against AIV or EIV. Despite the presence of AIV and EIV circulating among wild birds and horses in Mongolia, there was little evidence of AIV or EIV infection in this prospective study of Mongolians with animal exposures. © 2014 Khurelbaatar et al.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjectadult
dc.subjectantibody titer
dc.subjectarticle
dc.subjectavian influenza
dc.subjectavian influenza virus
dc.subjectbird
dc.subjectcamel
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectcross reaction
dc.subjectdisease severity
dc.subjectequine influenza
dc.subjectethnic group
dc.subjectexposure
dc.subjectfemale
dc.subjectfollow up
dc.subjecthorse
dc.subjecthuman
dc.subjectInfluenza virus
dc.subjectInfluenza virus A
dc.subjectInfluenza virus A H10N4
dc.subjectInfluenza virus A H1N1
dc.subjectInfluenza virus A H3N2
dc.subjectInfluenza virus A H3N8
dc.subjectInfluenza virus A H6N1
dc.subjectInfluenza virus A H9N2
dc.subjectmale
dc.subjectMongolia
dc.subjectMongolian
dc.subjectprospective study
dc.subjectreal time polymerase chain reaction
dc.subjectreverse transcription polymerase chain reaction
dc.subjectseroconversion
dc.subjectserology
dc.subjectAdult
dc.subjectAnimal Husbandry
dc.subjectAnimals
dc.subjectAntibodies, Viral
dc.subjectBirds
dc.subjectFemale
dc.subjectHorse Diseases
dc.subjectHorses
dc.subjectHumans
dc.subjectInfluenza A virus
dc.subjectInfluenza in Birds
dc.subjectInfluenza, Human
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMongolia
dc.subjectOccupational Exposure
dc.subjectOrthomyxoviridae Infections
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pone.0085616
dc.description.sourcetitlePLoS ONE
dc.description.volume9
dc.description.issue1
dc.description.pagee85616
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