Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0194878
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dc.titleWorking memory, age and education: A lifespan fMRI study
dc.contributor.authorArcher J.A.
dc.contributor.authorLee A.
dc.contributor.authorQiu A.
dc.contributor.authorChen S.-H.A.
dc.date.accessioned2020-03-23T06:22:13Z
dc.date.available2020-03-23T06:22:13Z
dc.date.issued2018
dc.identifier.citationArcher J.A., Lee A., Qiu A., Chen S.-H.A. (2018). Working memory, age and education: A lifespan fMRI study. PLoS ONE 13 (3) : e0194878. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0194878
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/165906
dc.description.abstractAgeing is associated with grey matter atrophy and changes in task-related neural activations. This study investigated the effects of age and education on neural activation during a spatial working memory task in 189 participants aged between 20-80 years old, whilst controlling for grey matter density. Age was related to linear decreases in neural activation in task activated areas, and this effect was no longer significant when adjusting for education or accuracy. Age was also related to cubic increases in neural activation in non-task related areas, such as the temporal gyrus, cuneus and cerebellum when adjusting for accuracy and education. These findings support previous lifespan datasets indicating linear age-related decreases in task activation, but non-linear increases in non-task related areas during episodic memory tasks. The findings also support past studies indicating education offers a form of cognitive reserve through providing a form of neural compensation and highlights the need to consider education in ageing studies. © 2018 Archer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjectadult
dc.subjectaged
dc.subjectaging
dc.subjectarticle
dc.subjectcognitive reserve
dc.subjectcompensation
dc.subjectcuneus
dc.subjecteducation
dc.subjectepisodic memory
dc.subjectfemale
dc.subjectfunctional magnetic resonance imaging
dc.subjectgray matter
dc.subjecthuman
dc.subjecthuman experiment
dc.subjectlifespan
dc.subjectmajor clinical study
dc.subjectmale
dc.subjecttemporal gyrus
dc.subjectworking memory
dc.subjectyoung adult
dc.subjectaging
dc.subjectbehavior
dc.subjectbrain
dc.subjectbrain mapping
dc.subjectdiagnostic imaging
dc.subjecteducational status
dc.subjectmiddle aged
dc.subjectneuropsychological test
dc.subjectnuclear magnetic resonance imaging
dc.subjectphysiology
dc.subjectshort term memory
dc.subjectspatial analysis
dc.subjecttask performance
dc.subjectAdult
dc.subjectAged
dc.subjectAging
dc.subjectBehavior
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectEducational Status
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMemory, Short-Term
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectSpatial Analysis
dc.subjectTask Performance and Analysis
dc.subjectYoung Adult
dc.typeArticle
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.description.doi10.1371/journal.pone.0194878
dc.description.sourcetitlePLoS ONE
dc.description.volume13
dc.description.issue3
dc.description.pagee0194878
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