Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0204996
DC Field | Value | |
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dc.title | The relationship between anogenital HPV types and incident HIV infection among men who have sex with men and transgender women in Lima, Peru: Findings from a prospective cohort study | |
dc.contributor.author | Brown B. | |
dc.contributor.author | Marg L. | |
dc.contributor.author | Leon S. | |
dc.contributor.author | Chen C. | |
dc.contributor.author | Siu J.N.Y. | |
dc.contributor.author | Calvo G. | |
dc.contributor.author | Sanchez H. | |
dc.contributor.author | Galea J.T. | |
dc.date.accessioned | 2020-03-23T06:18:53Z | |
dc.date.available | 2020-03-23T06:18:53Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Brown B., Marg L., Leon S., Chen C., Siu J.N.Y., Calvo G., Sanchez H., Galea J.T. (2018). The relationship between anogenital HPV types and incident HIV infection among men who have sex with men and transgender women in Lima, Peru: Findings from a prospective cohort study. PLoS ONE 13 (10) : e0204996. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0204996 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/165894 | |
dc.description.abstract | Although it is known that individuals living with HIV have a higher HPV prevalence, the impact of individual HPV types on HIV acquisition is less clear. In this prospective cohort study we investigated the relationship between HPV types and incident HIV infection among men who have sex with men (MSM) and transgender women (TW) in Lima, Peru. Six hundred HIV-negative Peruvian MSM and TW participated in a 2-year study with biannual visits. At baseline, participants completed a computerized, self-administered questionnaire on sexual behavior and HPV knowledge and underwent a physical exam including anogenital swabs for HPV DNA (37 genotypes via linear array testing) and HIV testing; follow-up visits included the questionnaire and HIV testing. Participant mean age was 25 years (range = 18-40), with 48.9% self-identifying as gay and 86.5% reporting having sex exclusively with men. At baseline, 530 participants had HPV DNA present (61.1% with high-risk HPV, 84.9% with low-risk HPV). Among 571 participants who returned for any study visit, 73 (12.8%) became infected with HIV during the 2-year follow-up (6% HIV incidence). Compared to those without HIV, more participants with HIV had any HPV type present (97.3% vs. 87.6%, respectively, p = .01), more than one HPV type (79.5% vs. 58.2%, p < .01), or high-risk HPV (72.6% vs. 51.4%, p < .01). Some participants lost to follow-up could have been HIV-positive, which would have affected the relationship of HPV and HIV infection. Our prospective study showed that participants with any HPV type, more than one HPV type, or high-risk HPV were more likely to test positive for HIV. Although most studies have shown HPV-HIV coinfection, our findings illustrate the strong relationship between individual HPV types and HIV infection. This further illustrates the potential utility of HPV vaccine for MSM and TW, not only for HPV prevention but also possibly for HIV prevention. © 2018 Brown et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.publisher | Public Library of Science | |
dc.source | Unpaywall 20200320 | |
dc.subject | Wart virus vaccine | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | attitude to health | |
dc.subject | cohort analysis | |
dc.subject | comorbidity | |
dc.subject | controlled study | |
dc.subject | disease association | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | genotype | |
dc.subject | homosexual male | |
dc.subject | human | |
dc.subject | Human immunodeficiency virus infection | |
dc.subject | incidence | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | male to female transgender | |
dc.subject | men who have sex with men and women | |
dc.subject | mixed infection | |
dc.subject | papillomavirus infection | |
dc.subject | Peru | |
dc.subject | Peruvian | |
dc.subject | physical examination | |
dc.subject | prospective study | |
dc.subject | questionnaire | |
dc.subject | risk factor | |
dc.subject | self concept | |
dc.subject | sexual behavior | |
dc.subject | Wart virus | |
dc.subject | adolescent | |
dc.subject | anal canal | |
dc.subject | genital system | |
dc.subject | Human immunodeficiency virus infection | |
dc.subject | incidence | |
dc.subject | isolation and purification | |
dc.subject | male homosexuality | |
dc.subject | Papillomaviridae | |
dc.subject | physiology | |
dc.subject | transgender | |
dc.subject | virology | |
dc.subject | young adult | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Anal Canal | |
dc.subject | Cohort Studies | |
dc.subject | Female | |
dc.subject | Genitalia | |
dc.subject | HIV Infections | |
dc.subject | Homosexuality, Male | |
dc.subject | Humans | |
dc.subject | Incidence | |
dc.subject | Male | |
dc.subject | Papillomaviridae | |
dc.subject | Peru | |
dc.subject | Prospective Studies | |
dc.subject | Transgender Persons | |
dc.subject | Young Adult | |
dc.type | Article | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1371/journal.pone.0204996 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 13 | |
dc.description.issue | 10 | |
dc.description.page | e0204996 | |
Appears in Collections: | Elements Staff Publications |
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