Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0156008
DC FieldValue
dc.titleIdentification of comprehensive geriatric assessment based risk factors for malnutrition in elderly Asian cancer patients
dc.contributor.authorTan T.
dc.contributor.authorOng W.S.
dc.contributor.authorRajasekaran T.
dc.contributor.authorKoo K.N.
dc.contributor.authorChan L.L.
dc.contributor.authorPoon D.
dc.contributor.authorChowdhury A.R.
dc.contributor.authorKrishna L.
dc.contributor.authorKanesvaran R.
dc.date.accessioned2020-03-19T07:48:21Z
dc.date.available2020-03-19T07:48:21Z
dc.date.issued2016
dc.identifier.citationTan T., Ong W.S., Rajasekaran T., Koo K.N., Chan L.L., Poon D., Chowdhury A.R., Krishna L., Kanesvaran R. (2016). Identification of comprehensive geriatric assessment based risk factors for malnutrition in elderly Asian cancer patients. PLoS ONE 11 (5) : e0156008. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0156008
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/165747
dc.description.abstractPurpose: Elderly cancer patients are at increased risk for malnutrition. We aim to identify comprehensive geriatric assessment (CGA) based clinical factors associated with increased nutritional risk and develop a clinical scoring system to identify nutritional risk in elderly cancer patients. Patients and Methods: CGA data was collected from 249 Asian patients aged 70 years or older. Nutritional risk was assessed based on the Nutrition Screening Initiative (NSI) checklist. Univariate and multivariate logistic regression analyses were applied to assess the association between patient clinical factors together with domains within the CGA and moderate to high nutritional risk. Goodness of fit was assessed using Hosmer-Lemeshow test. Discrimination ability was assessed based on the area under the receiver operating characteristics curve (AUC). Internal validation was performed using simulated datasets via bootstrapping. Results: Among the 249 patients, 184 (74%) had moderate to high nutritional risk. Multivariate logistic regression analysis identified stage 3-4 disease (Odds Ratio [OR] 2.54; 95% CI, 1.14-5.69), ECOG performance status of 2-4 (OR 3.04; 95% CI, 1.57-5.88), presence of depression (OR 5.99; 95% CI, 1.99-18.02) and haemoglobin levels <12 g/dL (OR 3.00; 95% CI 1.54-5.84) as significant independent factors associated with moderate to high nutritional risk. The model achieved good calibration (Hosmer-Lemeshow test's p = 0.17) and discrimination (AUC = 0.80). It retained good calibration and discrimination (bias-corrected AUC = 0.79) under internal validation. Conclusion: Having advanced stage of cancer, poor performance status, depression and anaemia were found to be predictors of moderate to high nutritional risk. Early identification of patients with these risk factors will allow for nutritional interventions that may improve treatment tolerance, quality of life and survival outcomes. © 2016 Tan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjecthemoglobin
dc.subjectaged
dc.subjectanemia
dc.subjectArticle
dc.subjectAsian
dc.subjectbootstrapping
dc.subjectcancer patient
dc.subjectcancer staging
dc.subjectclinical feature
dc.subjectcomprehensive geriatric assessment
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdiagnostic test accuracy study
dc.subjectEastern Cooperative Oncology Group performance status
dc.subjectfemale
dc.subjectfunctional status assessment
dc.subjectgeriatric assessment
dc.subjectgeriatric nutrition
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalnutrition
dc.subjectnutritional risk
dc.subjectreceiver operating characteristic
dc.subjectrisk factor
dc.subjectaged
dc.subjectcomplication
dc.subjectmalnutrition
dc.subjectneoplasm
dc.subjectnutritional assessment
dc.subjectpathology
dc.subjectquality of life
dc.subjectretrospective study
dc.subjectrisk assessment
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectFemale
dc.subjectGeriatric Assessment
dc.subjectHumans
dc.subjectMale
dc.subjectMalnutrition
dc.subjectNeoplasm Staging
dc.subjectNeoplasms
dc.subjectNutrition Assessment
dc.subjectQuality of Life
dc.subjectRetrospective Studies
dc.subjectRisk Assessment
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pone.0156008
dc.description.sourcetitlePLoS ONE
dc.description.volume11
dc.description.issue5
dc.description.pagee0156008
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1371_journal_pone_0156008.pdf356.19 kBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.