Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0119203
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dc.titleNo additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study
dc.contributor.authorAchterberg S.
dc.contributor.authorKappelle L.J.
dc.contributor.authorDe Bakker P.I.W.
dc.contributor.authorTraylor M.
dc.contributor.authorAlgra A.
dc.contributor.authorVan Der Graaf Y.
dc.contributor.authorGrobbee D.E.
dc.contributor.authorRutten G.E.H.M.
dc.contributor.authorVisseren F.L.J.
dc.contributor.authorMoll F.L.
dc.contributor.authorMali W.P.T.M.
dc.contributor.authorDoevendans P.A.
dc.contributor.authorMartin F.
dc.contributor.authorHolliday E.G.
dc.contributor.authorSudlow C.
dc.contributor.authorHopewell J.C.
dc.contributor.authorCheng Y.-C.
dc.contributor.authorFornage M.
dc.contributor.authorIkram M.A.
dc.contributor.authorMalik R.
dc.contributor.authorBevan S.
dc.contributor.authorThorsteinsdottir U.
dc.contributor.authorDeStefano A.L.
dc.contributor.authorWorrall B.B.
dc.contributor.authorReiner A.P.
dc.contributor.authorMitchell B.D.
dc.contributor.authorClarke R.
dc.contributor.authorLevi C.
dc.contributor.authorSeshadri S.
dc.contributor.authorBoncoraglio G.B.
dc.contributor.authorSharma P.
dc.contributor.authorBis J.C.
dc.contributor.authorGretarsdottir S.
dc.contributor.authorPsaty B.M.
dc.contributor.authorRothwell P.M.
dc.contributor.authorRosand J.
dc.contributor.authorMeschia J.F.
dc.contributor.authorStefansson K.
dc.contributor.authorDichgans M.
dc.contributor.authorMarkus H.S.
dc.date.accessioned2020-03-19T03:02:28Z
dc.date.available2020-03-19T03:02:28Z
dc.date.issued2015
dc.identifier.citationAchterberg S., Kappelle L.J., De Bakker P.I.W., Traylor M., Algra A., Van Der Graaf Y., Grobbee D.E., Rutten G.E.H.M., Visseren F.L.J., Moll F.L., Mali W.P.T.M., Doevendans P.A., Martin F., Holliday E.G., Sudlow C., Hopewell J.C., Cheng Y.-C., Fornage M., Ikram M.A., Malik R., Bevan S., Thorsteinsdottir U., DeStefano A.L., Worrall B.B., Reiner A.P., Mitchell B.D., Clarke R., Levi C., Seshadri S., Boncoraglio G.B., Sharma P., Bis J.C., Gretarsdottir S., Psaty B.M., Rothwell P.M., Rosand J., Meschia J.F., Stefansson K., Dichgans M., Markus H.S. (2015). No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study. PLoS ONE 10 (4) : e0119203. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0119203
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/165699
dc.description.abstractBackground: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that cerebral ischemia has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. Methods and Results: We studied 1020 patients with cerebral ischemia and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new ischemic events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of ischemic stroke (using summary statistics from the METASTROKE study which included 12389 cases and 62004 controls), the AUC-ROC remained the same. Similar results were found for the secondary outcome ischemic stroke. Conclusions: We found no additional value of genetic information in a prognostic model for the risk of ischemic events in patients with cerebral ischemia of arterial origin. This is consistent with a complex, polygenic architecture, where many genes of weak effect likely act in concert to influence the heritable risk of an individual to develop (recurrent) vascular events. At present, genetic information cannot help clinicians to distinguish patients at high risk for recurrent vascular events. © 2015 Achterberg et al.
dc.publisherPublic Library of Science
dc.sourceUnpaywall 20200320
dc.subjectadult
dc.subjectaged
dc.subjectarea under the curve
dc.subjectArticle
dc.subjectbrain ischemia
dc.subjectcardiovascular disease
dc.subjectcardiovascular risk
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollow up
dc.subjectgenetic association
dc.subjectgenetic risk
dc.subjectgenotyping technique
dc.subjectheart infarction
dc.subjectheredity
dc.subjecthuman
dc.subjectincidence
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprediction
dc.subjectprognosis
dc.subjectreceiver operating characteristic
dc.subjectrisk factor
dc.subjectsingle nucleotide polymorphism
dc.subjectvascular disease
dc.subjectartery
dc.subjectbrain infarction
dc.subjectbrain ischemia
dc.subjectcerebrovascular accident
dc.subjectgenetics
dc.subjectgenome-wide association study
dc.subjectgenotype
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectprocedures
dc.subjectrisk factor
dc.subjectAged
dc.subjectArea Under Curve
dc.subjectArteries
dc.subjectBrain Ischemia
dc.subjectCerebral Infarction
dc.subjectFemale
dc.subjectGenome-Wide Association Study
dc.subjectGenotype
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectROC Curve
dc.subjectStroke
dc.subjectVascular Diseases
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pone.0119203
dc.description.sourcetitlePLoS ONE
dc.description.volume10
dc.description.issue4
dc.description.pagee0119203
dc.published.statePublished
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