Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/163865
DC FieldValue
dc.titleInducible nitric oxide synthase and bcl-2 expression in nasopharyngeal cancer: Correlation with outcome of patients after radiotherapy
dc.contributor.authorJayasurya, A
dc.contributor.authorDheen, ST
dc.contributor.authorYap, WM
dc.contributor.authorTan, NG
dc.contributor.authorNg, YK
dc.contributor.authorBay, BH
dc.date.accessioned2020-01-20T01:20:55Z
dc.date.available2020-01-20T01:20:55Z
dc.date.issued2003-07-01
dc.identifier.citationJayasurya, A, Dheen, ST, Yap, WM, Tan, NG, Ng, YK, Bay, BH (2003-07-01). Inducible nitric oxide synthase and bcl-2 expression in nasopharyngeal cancer: Correlation with outcome of patients after radiotherapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 56 (3) : 837-845. ScholarBank@NUS Repository.
dc.identifier.issn03603016
dc.identifier.issn1879355X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/163865
dc.description.abstractPurpose: The expression of inducible nitric oxide synthase (iNOS) and bcl-2 proteins was evaluated and the prognostic significance determined in nasopharyngeal cancer (NPC) patients treated by radiotherapy. Methods and Materials: Tissue sections from 55 patients with NPC were assessed for iNOS and bcl-2 protein expression by immunohistochemistry, immunoelectron microscopy, and in situ hybridization before treatment. The markers were correlated with apoptosis (detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay) and clinicopathologic parameters. Results: All NPC sections exhibited positive iNOS and bcl-2 immunoreactivity, with a mean percentage of 6.24% ± 0.58% and 17.09% ± 2.48%, respectively. A significant positive correlation was observed between iNOS expression and the apoptotic index (p < 0.0001, Pearson's r = 0.8518), and bcl-2 expression correlated inversely with apoptosis (p = 0.0001; Pearson's r = -0.6170). A significant inverse correlation was found between iNOS and bcl-2 immunoreactivity (p < 0.0001, Pearson's r = -0.7144). Bcl-2 but not iNOS expression was associated with the stage of the tumor according to the criteria of the American Joint Committee on Cancer (1997) (p < 0.0001). Patients who had recurrence of the tumor and metastasis after radiotherapy had a lower expression of iNOS (p = 0.014 and p = 0.035, respectively), although overall survival was not significantly different statistically. Higher bcl-2 expression was also associated with local tumor recurrence (p = 0.005) but not with metastasis or overall survival. Conclusion: It appears that iNOS and bcl-2 expression may be potentially useful biomarkers for predicting the outcome of radiotherapy in NPC patients.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0360-3016(03)00122-6
dc.language.isoen
dc.publisherELSEVIER
dc.sourceElements
dc.subjectApoptosis
dc.subjectBiomarkers
dc.subjectImmunohistochemistry
dc.subjectIn situ hybridization
dc.subjectNasopharyngeal carcinoma
dc.typeArticle
dc.date.updated2020-01-17T08:02:52Z
dc.contributor.departmentDEPT OF ANATOMY
dc.description.sourcetitleINTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
dc.description.volume56
dc.description.issue3
dc.description.page837-845
dc.description.codenIOBPD
dc.identifier.isiut000183361800031
dc.description.placeUnited States
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2003_Jayasurya et al_Int. J. Radiation Oncology Biol. Phys..pdf388.3 kBAdobe PDF

CLOSED

None

Page view(s)

57
checked on Aug 6, 2020

Download(s)

1
checked on Aug 6, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.