Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0033407
DC FieldValue
dc.titleAging kit mutant mice develop cardiomyopathy
dc.contributor.authorYe L.
dc.contributor.authorZhang E.Y.
dc.contributor.authorXiong Q.
dc.contributor.authorAstle C.M.
dc.contributor.authorZhang P.
dc.contributor.authorLi Q.
dc.contributor.authorFrom A.H.L.
dc.contributor.authorHarrison D.E.
dc.contributor.authorZhang J.J.
dc.date.accessioned2019-11-11T06:41:31Z
dc.date.available2019-11-11T06:41:31Z
dc.date.issued2012
dc.identifier.citationYe L., Zhang E.Y., Xiong Q., Astle C.M., Zhang P., Li Q., From A.H.L., Harrison D.E., Zhang J.J. (2012). Aging kit mutant mice develop cardiomyopathy. PLoS ONE 7 (3) : e33407. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0033407
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161995
dc.description.abstractBoth bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit + cells counts and ii. the stability of left ventricular (LV) contractile function and structure during aging. LV structure and contractile function were evaluated (echocardiography) in two groups of Kit mutant (W/Wv and W41/W42) and in wild type (WT) mice at 4 and 12 months of age and the effects of the mutations on LV mass, vascular density and the numbers of proliferating cells were also determined. In 4 month old Kit mutant and WT mice, LV ejection fractions (EF) and LV fractional shortening rates (FS) were comparable. At 12 months of age EF and FS were significantly decreased and LV mass was significantly increased only in W41/W42 mice. Myocardial vascular densities and c-Kit + cell numbers were significantly reduced in both mutant groups when compared to WT hearts. Replacement of mutant BM with WT BM at 4 months of age did not prevent these abnormalities in either mutant group although they were somewhat attenuated in the W/Wv group. Notably BM transplantation did not prevent the development of cardiomyopathy in 12 month W41/W42 mice. The data suggest that decreased numbers and functional capacities of c-Kit + cardiac resident progenitor cells may be the basis of the cardiomyopathy in W41/W42 mice and although defects in mutant BM progenitor cells may prove to be contributory, they are not causal. © 2012 Ye et al.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20191101
dc.subjectstem cell factor receptor
dc.subjectgreen fluorescent protein
dc.subjectstem cell factor receptor
dc.subjectaging
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectblood vessel parameters
dc.subjectbone marrow transplantation
dc.subjectcardiomyopathy
dc.subjectcell count
dc.subjectcell proliferation
dc.subjectcontrolled study
dc.subjectheart left ventricle contraction
dc.subjectheart left ventricle ejection fraction
dc.subjectheart left ventricle mass
dc.subjectheart muscle cell
dc.subjectmouse
dc.subjectmutant
dc.subjectmutation
dc.subjectnonhuman
dc.subjectvascular density
dc.subjectwild type
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectC57BL mouse
dc.subjectcomparative study
dc.subjectcytology
dc.subjectechocardiography
dc.subjectenzymology
dc.subjectgenetics
dc.subjectheart ventricle
dc.subjectimmunohistochemistry
dc.subjectmetabolism
dc.subjectmouse mutant
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectsystole
dc.subjectMus
dc.subjectAging
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBone Marrow Transplantation
dc.subjectCardiomyopathies
dc.subjectCell Count
dc.subjectEchocardiography
dc.subjectGreen Fluorescent Proteins
dc.subjectHeart Ventricles
dc.subjectImmunohistochemistry
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectMice, Mutant Strains
dc.subjectMutation
dc.subjectProto-Oncogene Proteins c-kit
dc.subjectSystole
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentNUSHS PROJECT
dc.description.doi10.1371/journal.pone.0033407
dc.description.sourcetitlePLoS ONE
dc.description.volume7
dc.description.issue3
dc.description.pagee33407
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1371_journal_pone_0033407.pdf1.28 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

12
checked on Jan 20, 2021

Page view(s)

107
checked on Jan 15, 2021

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons