Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0115741
Title: Clonal analysis of meningococci during a 26 year period prior to the introduction of meningococcal serogroup C vaccines
Authors: Sullivan C.B.
Diggle M.A.
Davies R.L.
Clarke S.C. 
Keywords: Meningococcus vaccine
Article
bacterial genome
bacterium identification
bacterium isolate
clonal variation
controlled study
human
molecular cloning
molecular dynamics
multilocus sequence typing
Neisseria meningitidis
nonhuman
organisms by geographical distribution
retrospective study
sequence analysis
serotype
species diversity
pH
retracted article
Neisseria meningitidis
Hydrogen-Ion Concentration
Issue Date: 2015
Citation: Sullivan C.B., Diggle M.A., Davies R.L., Clarke S.C. (2015). Clonal analysis of meningococci during a 26 year period prior to the introduction of meningococcal serogroup C vaccines. PLoS ONE 10 (1) : e115741. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0115741
Rights: Attribution 4.0 International
Abstract: Meningococcal disease remains a public health burden in the UK and elsewhere. Invasive Neisseria meningitidis, isolated in Scotland between 1972 and 1998, were characterised retrospectively to examine the serogroup and clonal structure of the circulating population. 2607 isolates causing invasive disease were available for serogroup and MLST analysis whilst 2517 were available for multilocus sequence typing (MLST) analysis only. Serogroup distribution changed from year to year but serogroups B and C were dominant throughout. Serogroup B was dominant throughout the 1970s and early 1980s until serogroup C became dominant during the mid-1980s. The increase in serogroup C was not associated with one particular sequence type (ST) but was associated with a number of STs, including ST-8, ST-11, ST-206 and ST-334. This is in contrast to the increase in serogroup C disease seen in the 1990s that was due to expansion of the ST-11 clonal complex. While there was considerable diversity among the isolates (309 different STs among the 2607 isolates), a large proportion of isolates (59.9%) were associated with only 10 STs. These data highlight meningococcal diversity over time and the need for ongoing surveillance during the introduction of new meningococcal vaccines. © 2015 Sullivan et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161751
ISSN: 19326203
DOI: 10.1371/journal.pone.0115741
Rights: Attribution 4.0 International
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