Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0117044
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dc.title | Association between family history risk categories and prevalence of diabetes in chinese population | |
dc.contributor.author | Zhang J. | |
dc.contributor.author | Yang Z. | |
dc.contributor.author | Xiao J. | |
dc.contributor.author | Xing X. | |
dc.contributor.author | Lu J. | |
dc.contributor.author | Weng J. | |
dc.contributor.author | Jia W. | |
dc.contributor.author | Ji L. | |
dc.contributor.author | Shan Z. | |
dc.contributor.author | Liu J. | |
dc.contributor.author | Tian H. | |
dc.contributor.author | Ji Q. | |
dc.contributor.author | Zhu D. | |
dc.contributor.author | Ge J. | |
dc.contributor.author | Chen L. | |
dc.contributor.author | Guo X. | |
dc.contributor.author | Zhao Z. | |
dc.contributor.author | Li Q. | |
dc.contributor.author | Zhou Z. | |
dc.contributor.author | Lin L. | |
dc.contributor.author | Wang N. | |
dc.contributor.author | Yang W. | |
dc.date.accessioned | 2019-11-07T05:02:12Z | |
dc.date.available | 2019-11-07T05:02:12Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Zhang J., Yang Z., Xiao J., Xing X., Lu J., Weng J., Jia W., Ji L., Shan Z., Liu J., Tian H., Ji Q., Zhu D., Ge J., Chen L., Guo X., Zhao Z., Li Q., Zhou Z., Lin L., Wang N., Yang W. (2015). Association between family history risk categories and prevalence of diabetes in chinese population. PLoS ONE 10 (2) : e0117044. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0117044 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161746 | |
dc.description.abstract | Aim To investigate the association between different family history risk categories and prevalence of diabetes in the Chinese population. Methods The family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey of 46,239 individuals (age ?20 years) in the 2007-2008 China National Diabetes and Metabolism Disorders Study. The family history risk categories of diabetes were high, moderate, and average (FH2 and FH1: at least two generations and one generation of first-degree relatives with diabetes, respectively; FH0: no first-degree relatives with diabetes). Results The age- and gender-adjusted prevalence rates of diabetes were 32.7% (95% confidence interval (CI): 26.4-39.7%) in FH2, 20.1% (95% CI: 18.2- 22.1%) in FH1, and 8.4% (95% CI: 7.9-8.9%) in FH0 (P < 0.0001). The calculated homeostatic model assessment-estimated insulin resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI), and insulinogenic index (?I30/ ÄG30) values showed significant trending changes among the three risk categories, with the most negative effects in FH2. Multivariate logistic regression analysis showed that the odds ratios of having diabetes were 6.16 (95% CI: 4.46- 8.50) and 2.86 (95% CI: 2.41-3.39) times higher in FH2 and FH1, respectively, than in FH0 after adjustment for classical risk factors for diabetes. Conclusions Family history risk categories of diabetes have a significant, independent, and graded association with the prevalence of this disease in the Chinese population.. © 2015 Zhang et al. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20191101 | |
dc.subject | cholesterol | |
dc.subject | glucose | |
dc.subject | insulin | |
dc.subject | low density lipoprotein cholesterol | |
dc.subject | triacylglycerol | |
dc.subject | insulin | |
dc.subject | adult | |
dc.subject | age distribution | |
dc.subject | Article | |
dc.subject | assessment of humans | |
dc.subject | body mass | |
dc.subject | Chinese | |
dc.subject | classification | |
dc.subject | comparative study | |
dc.subject | controlled study | |
dc.subject | cross-sectional study | |
dc.subject | diabetes mellitus | |
dc.subject | disease association | |
dc.subject | family history | |
dc.subject | female | |
dc.subject | first degree relative | |
dc.subject | glucose blood level | |
dc.subject | high risk population | |
dc.subject | homeostatic model assessment estimated insulin resistance | |
dc.subject | human | |
dc.subject | insulin blood level | |
dc.subject | insulin release | |
dc.subject | insulin resistance | |
dc.subject | insulinogenic index | |
dc.subject | low risk population | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | Matsuda insulin sensitivity index | |
dc.subject | middle aged | |
dc.subject | obesity | |
dc.subject | onset age | |
dc.subject | oral glucose tolerance test | |
dc.subject | prevalence | |
dc.subject | retrospective study | |
dc.subject | risk assessment | |
dc.subject | risk factor | |
dc.subject | trend study | |
dc.subject | young adult | |
dc.subject | China | |
dc.subject | diabetes mellitus | |
dc.subject | glucose intolerance | |
dc.subject | metabolism | |
dc.subject | physiology | |
dc.subject | population | |
dc.subject | prevalence | |
dc.subject | secretion (process) | |
dc.subject | Adult | |
dc.subject | China | |
dc.subject | Diabetes Mellitus | |
dc.subject | Female | |
dc.subject | Glucose Intolerance | |
dc.subject | Humans | |
dc.subject | Insulin | |
dc.subject | Insulin Resistance | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Population | |
dc.subject | Prevalence | |
dc.subject | Risk Factors | |
dc.subject | Young Adult | |
dc.type | Article | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1371/journal.pone.0117044 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 10 | |
dc.description.issue | 2 | |
dc.description.page | e0117044 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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