Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0120272
DC Field | Value | |
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dc.title | Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety onee0120272 | |
dc.contributor.author | Dine J. | |
dc.contributor.author | Ionescu I.A. | |
dc.contributor.author | Avrabos C. | |
dc.contributor.author | Yen Y.-C. | |
dc.contributor.author | Holsboer F. | |
dc.contributor.author | Landgraf R. | |
dc.contributor.author | Schmidt U. | |
dc.contributor.author | Eder M. | |
dc.date.accessioned | 2019-11-06T01:33:11Z | |
dc.date.available | 2019-11-06T01:33:11Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Dine J., Ionescu I.A., Avrabos C., Yen Y.-C., Holsboer F., Landgraf R., Schmidt U., Eder M. (2015). Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety onee0120272. PLoS ONE 10 (4) : e0120272. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0120272 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161525 | |
dc.description.abstract | The neurobiological basis of pathological anxiety and the improvement of its pharmacological treatment are a matter of intensive investigation. Here, using electrophysiological techniques in brain slices from animals of the high anxiety-related behavior (HAB) and normal anxiety-related behavior (NAB) mouse model, we show that basal neurotransmission at ventral hippocampal CA3-CA1 synapses is weaker in HAB compared to NAB mice. We further demonstrate that paired-pulse facilitation (PPF) and long-term potentiation (LTP) at these synapses are more pronounced in slices from HAB animals. Based on previous findings, we also examined whether intranasal delivery of neuropeptide S (NPS), which increasingly emerges as a potential novel treatment option for anxiety symptoms occurring in a variety of diseases like anxiety disorders, posttraumatic stress disorder, and major depression, impacts on the high-anxiety electrophysiological endophenotype in HAB mice. Strikingly, we detected enhanced basal neurotransmission and reduced PPF and LTP in slices from NPS-treated HAB animals. Collectively, our study uncovers a multifaceted highanxiety neurophysiological endophenotype in the murine ventral hippocampus and provides the first evidence that an intranasally applied neuropeptide can shift such an endophenotype in an anxiety-regulating brain structure towards a "normal"-anxiety one. © 2015 Dine et al. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20191101 | |
dc.subject | neuropeptide S | |
dc.subject | neuropeptide | |
dc.subject | animal behavior | |
dc.subject | animal cell | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | animal tissue | |
dc.subject | anxiety | |
dc.subject | anxiety disorder | |
dc.subject | Article | |
dc.subject | brain electrophysiology | |
dc.subject | brain slice | |
dc.subject | controlled study | |
dc.subject | endophenotype | |
dc.subject | hippocampal CA1 region | |
dc.subject | hippocampal CA3 region | |
dc.subject | hippocampus | |
dc.subject | long term potentiation | |
dc.subject | male | |
dc.subject | mouse | |
dc.subject | neurotransmission | |
dc.subject | nonhuman | |
dc.subject | paired pulse facilitation | |
dc.subject | synapse | |
dc.subject | synaptic potential | |
dc.subject | tranquilizing activity | |
dc.subject | ventral hippocampus | |
dc.subject | animal | |
dc.subject | drug effects | |
dc.subject | electrophysiology | |
dc.subject | endophenotype | |
dc.subject | hippocampus | |
dc.subject | intranasal drug administration | |
dc.subject | pathophysiology | |
dc.subject | physiology | |
dc.subject | synaptic transmission | |
dc.subject | Animalia | |
dc.subject | Murinae | |
dc.subject | Mus | |
dc.subject | Administration, Intranasal | |
dc.subject | Animals | |
dc.subject | Anxiety | |
dc.subject | Behavior, Animal | |
dc.subject | Electrophysiological Processes | |
dc.subject | Endophenotypes | |
dc.subject | Hippocampus | |
dc.subject | Long-Term Potentiation | |
dc.subject | Male | |
dc.subject | Mice | |
dc.subject | Neuropeptides | |
dc.subject | Synapses | |
dc.subject | Synaptic Transmission | |
dc.type | Article | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.1371/journal.pone.0120272 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 10 | |
dc.description.issue | 4 | |
dc.description.page | e0120272 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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