Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0096149
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dc.titleReplication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries
dc.contributor.authorTan L.-J.
dc.contributor.authorZhu H.
dc.contributor.authorHe H.
dc.contributor.authorWu K.-H.
dc.contributor.authorLi J.
dc.contributor.authorChen X.-D.
dc.contributor.authorZhang J.-G.
dc.contributor.authorShen H.
dc.contributor.authorTian Q.
dc.contributor.authorKrousel-Wood M.
dc.contributor.authorPapasian C.J.
dc.contributor.authorBouchard C.
dc.contributor.authorPérusse L.
dc.contributor.authorDeng H.-W.
dc.date.accessioned2019-11-05T00:36:47Z
dc.date.available2019-11-05T00:36:47Z
dc.date.issued2014
dc.identifier.citationTan L.-J., Zhu H., He H., Wu K.-H., Li J., Chen X.-D., Zhang J.-G., Shen H., Tian Q., Krousel-Wood M., Papasian C.J., Bouchard C., Pérusse L., Deng H.-W. (2014). Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries. PLoS ONE 9 (5) : e96149. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0096149
dc.identifier.issn1932-6203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161408
dc.description.abstractObesity is a major public health problem with a significant genetic component. Multiple DNA polymorphisms/genes have been shown to be strongly associated with obesity, typically in populations of European descent. The aim of this study was to verify the extent to which 6 confirmed obesity genes (FTO, CTNNBL1, ADRB2, LEPR, PPARG and UCP2 genes) could be replicated in 8 different samples (n = 11,161) and to explore whether the same genes contribute to obesity-susceptibility in populations of different ancestries (five Caucasian, one Chinese, one African-American and one Hispanic population). GWAS-based data sets with 1000 G imputed variants were tested for association with obesity phenotypes individually in each population, and subsequently combined in a meta-analysis. Multiple variants at the FTO locus showed significant associations with BMI, fat mass (FM) and percentage of body fat (PBF) in meta-analysis. The strongest association was detected at rs7185735 (P-value = 1.01 × 10-7 for BMI, 1.80 × 10-6 for FM, and 5.29 × 10-4 for PBF). Variants at the CTNNBL1, LEPR and PPARG loci demonstrated nominal association with obesity phenotypes (meta-analysis P-values ranging from 1.15 × 10-3 to 4.94 × 10 -2). There was no evidence of association with variants at ADRB2 and UCP2 genes. When stratified by sex and ethnicity, FTO variants showed sex-specific and ethnic-specific effects on obesity traits. Thus, it is likely that FTO has an important role in the sex- and ethnic-specific risk of obesity. Our data confirmed the role of FTO, CTNNBL1, LEPR and PPARG in obesity predisposition. These findings enhanced our knowledge of genetic associations between these genes and obesity-related phenotypes, and provided further justification for pursuing functional studies of these genes in the pathophysiology of obesity. Sex and ethnic differences in genetic susceptibility across populations of diverse ancestries may contribute to a more targeted prevention and customized treatment of obesity. © 2014 Tan et al.
dc.sourceUnpaywall 20191101
dc.subjectDNA
dc.subjectuncoupling protein 2
dc.subjectADRB2 gene
dc.subjectAfrican American
dc.subjectarticle
dc.subjectbody fat
dc.subjectbody mass
dc.subjectCaucasian
dc.subjectChinese
dc.subjectCTNNBL1 gene
dc.subjectdisease predisposition
dc.subjectDNA polymorphism
dc.subjectethnic difference
dc.subjectfemale
dc.subjectFTO gene
dc.subjectgene
dc.subjectgene replication
dc.subjectgenetic association
dc.subjectgenetic susceptibility
dc.subjectgenetic variability
dc.subjectgenotype
dc.subjectHispanic
dc.subjecthuman
dc.subjectLEPR gene
dc.subjectmale
dc.subjectmeta analysis
dc.subjectobesity
dc.subjectpathophysiology
dc.subjectphenotype
dc.subjectPPARG gene
dc.subjectsex difference
dc.subjectsingle nucleotide polymorphism
dc.subjectucp2 gene
dc.subjectancestry group
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectobesity
dc.subjectreproducibility
dc.subjectContinental Population Groups
dc.subjectGenetic Predisposition to Disease
dc.subjectGenome-Wide Association Study
dc.subjectHumans
dc.subjectObesity
dc.subjectPhenotype
dc.subjectReproducibility of Results
dc.typeArticle
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.description.doi10.1371/journal.pone.0096149
dc.description.sourcetitlePLoS ONE
dc.description.volume9
dc.description.issue5
dc.description.pagee96149
dc.published.statePublished
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