Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0054793
DC Field | Value | |
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dc.title | Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients | |
dc.contributor.author | Ezzikouri S. | |
dc.contributor.author | Alaoui R. | |
dc.contributor.author | Rebbani K. | |
dc.contributor.author | Brahim I. | |
dc.contributor.author | Fakhir F.-Z. | |
dc.contributor.author | Nadir S. | |
dc.contributor.author | Diepolder H. | |
dc.contributor.author | Khakoo S.I. | |
dc.contributor.author | Thursz M. | |
dc.contributor.author | Benjelloun S. | |
dc.date.accessioned | 2019-11-04T06:31:02Z | |
dc.date.available | 2019-11-04T06:31:02Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Ezzikouri S., Alaoui R., Rebbani K., Brahim I., Fakhir F.-Z., Nadir S., Diepolder H., Khakoo S.I., Thursz M., Benjelloun S. (2013). Genetic Variation in the Interleukin-28B Gene Is Associated with Spontaneous Clearance and Progression of Hepatitis C Virus in Moroccan Patients. PLoS ONE 8 (1) : e54793. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0054793 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161349 | |
dc.description.abstract | Background: Genetic variation in the IL28B gene has been strongly associated with treatment outcomes, spontaneous clearance and progression of the hepatitis C virus infection (HCV). The aim of the present study was to investigate the role of polymorphisms at this locus with progression and outcome of HCV infection in a Moroccan population. Methods: We analyzed a cohort of 438 individuals among them 232 patients with persistent HCV infection, of whom 115 patients had mild chronic hepatitis and 117 had advanced liver disease (cirrhosis and hepatocellular carcinoma), 68 individuals who had naturally cleared HCV and 138 healthy subjects. The IL28B SNPs rs12979860 and rs8099917 were genotyped using a TaqMan 5? allelic discrimination assay. Results: The protective rs12979860-C and rs8099917-T alleles were more common in subjects with spontaneous clearance (77.9% vs 55.2%; p = 0.00001 and 95.6% vs 83.2%; p = 0.0025, respectively). Individuals with clearance were 4.69 (95% CI, 1.99-11.07) times more likely to have the C/C genotype for rs12979860 polymorphism (p = 0.0017) and 3.55 (95% CI, 0.19-66.89) times more likely to have the T/T genotype at rs8099917. Patients with advanced liver disease carried the rs12979860-T/T genotype more frequently than patients with mild chronic hepatitis C (OR = 1.89; 95% CI, 0.99-3.61; p = 0.0532) and this risk was even more pronounced when we compared them with healthy controls (OR = 4.27; 95% CI, 2.08-8.76; p = 0.0005). The rs8099917-G allele was also associated with advanced liver disease (OR = 2.34; 95% CI, 1.40-3.93; p = 0.0100). Conclusions: In the Moroccan population, polymorphisms near the IL28B gene play a role both in spontaneous clearance and progression of HCV infection. © 2013 Ezzikouri et al. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20191101 | |
dc.subject | cysteine | |
dc.subject | interleukin 28B | |
dc.subject | threonine | |
dc.subject | adolescent | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | allele | |
dc.subject | article | |
dc.subject | chronic hepatitis | |
dc.subject | cohort analysis | |
dc.subject | controlled study | |
dc.subject | disease course | |
dc.subject | ethnic group | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | gene expression regulation | |
dc.subject | gene frequency | |
dc.subject | gene function | |
dc.subject | gene location | |
dc.subject | gene locus | |
dc.subject | genetic association | |
dc.subject | genetic variability | |
dc.subject | genotype | |
dc.subject | hepatitis C | |
dc.subject | Hepatitis C virus | |
dc.subject | human | |
dc.subject | interleukin 28B gene | |
dc.subject | liver cell carcinoma | |
dc.subject | liver cirrhosis | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | Morocco | |
dc.subject | nonhuman | |
dc.subject | outcome assessment | |
dc.subject | single nucleotide polymorphism | |
dc.subject | viral clearance | |
dc.subject | virus load | |
dc.subject | Aged | |
dc.subject | Alleles | |
dc.subject | Base Sequence | |
dc.subject | Cohort Studies | |
dc.subject | DNA Primers | |
dc.subject | Female | |
dc.subject | Hepatitis C | |
dc.subject | Humans | |
dc.subject | Interleukins | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Morocco | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | |
dc.subject | Hepatitis C virus | |
dc.type | Article | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.1371/journal.pone.0054793 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 8 | |
dc.description.issue | 1 | |
dc.description.page | e54793 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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