Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0202147
DC Field | Value | |
---|---|---|
dc.title | Surveillance for respiratory syncytial virus and parainfluenza virus among patients hospitalized with pneumonia in Sarawak, Malaysia | |
dc.contributor.author | Fieldhouse J.K. | |
dc.contributor.author | Toh T.-H. | |
dc.contributor.author | Lim W.-H. | |
dc.contributor.author | Ting J. | |
dc.contributor.author | Ha S.-J. | |
dc.contributor.author | Hii K.-C. | |
dc.contributor.author | Kong C.-I. | |
dc.contributor.author | Wong T.-M. | |
dc.contributor.author | Wong S.-C. | |
dc.contributor.author | Warkentien T.E. | |
dc.contributor.author | Gray G.C. | |
dc.date.accessioned | 2019-11-01T08:17:44Z | |
dc.date.available | 2019-11-01T08:17:44Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Fieldhouse J.K., Toh T.-H., Lim W.-H., Ting J., Ha S.-J., Hii K.-C., Kong C.-I., Wong T.-M., Wong S.-C., Warkentien T.E., Gray G.C. (2018). Surveillance for respiratory syncytial virus and parainfluenza virus among patients hospitalized with pneumonia in Sarawak, Malaysia. PLoS ONE 13 (8) : e0202147. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0202147 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161240 | |
dc.description.abstract | Background: Respiratory syncytial virus (RSV) and parainfluenza virus (PIV) are frequent causes of pneumonia and death among children at Sibu and Kapit Hospitals in Sarawak, Malaysia. Objectives To determine the prevalence and risk factors for RSV subtypes A and B and PIV types 1±4 among patients hospitalized with pneumonia. Methods: In a cross-sectional, pilot study nasopharyngeal swabs were studied with real-time reverse transcription polymerase chain reaction assays. Concurrently, we helped Sibu and Kapit Hospitals adapt their first molecular diagnostics for RSV and PIV. Results: Of 129 specimens collected (June to July 2017), 39 tested positive for RSV-A (30.2%), two were positive for RSV B (1.6%), one was positive for PIV-3 (0.8%) and one was positive for PIV-4 (0.8%). No samples were positive for PIV-1 or PIV-2. Of the 39 RSV-A positive specimens, 46.2% were collected from children under one year of age and only 5.1% were from patients over the age of 18. A multivariable analysis found the odds of children <1 year of age testing positive for RSV-A were 32.7 (95% CI: 3.9, 276.2) times larger than >18 years of age, and the odds of patients hospitalized at Kapit Hospital testing positive for RSV-A were 3.2 (95% CI: 1.3, 7.8) times larger than patients hospitalized at Sibu Hospital. Conclusion: This study found an unusually high prevalence of RSV-A among pneumonia patients admitted to the two hospitals. Subsequently, Sibu Hospital adapted the molecular assays with the goal of providing more directed care for such pneumonia patients. © 2018 Public Library of Science. All rights reserved. | |
dc.rights | CC0 1.0 Universal | |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | |
dc.source | Unpaywall 20191101 | |
dc.subject | adolescent | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | child | |
dc.subject | cross-sectional study | |
dc.subject | human | |
dc.subject | Human parainfluenza virus 1 | |
dc.subject | Human parainfluenza virus 2 | |
dc.subject | Human parainfluenza virus 3 | |
dc.subject | Human parainfluenza virus 4 | |
dc.subject | Human respiratory syncytial virus | |
dc.subject | Human respiratory syncytial virus A | |
dc.subject | Human respiratory syncytial virus B | |
dc.subject | infant | |
dc.subject | infection risk | |
dc.subject | major clinical study | |
dc.subject | Malaysia | |
dc.subject | molecular diagnosis | |
dc.subject | nonhuman | |
dc.subject | Paramyxovirinae | |
dc.subject | pilot study | |
dc.subject | pneumonia | |
dc.subject | prevalence | |
dc.subject | real time polymerase chain reaction | |
dc.subject | reverse transcription polymerase chain reaction | |
dc.subject | risk factor | |
dc.subject | throat culture | |
dc.subject | virus identification | |
dc.subject | classification | |
dc.subject | female | |
dc.subject | genetics | |
dc.subject | health survey | |
dc.subject | hospitalization | |
dc.subject | Human respiratory syncytial virus | |
dc.subject | Malaysia | |
dc.subject | male | |
dc.subject | newborn | |
dc.subject | odds ratio | |
dc.subject | paramyxovirus infection | |
dc.subject | preschool child | |
dc.subject | respiratory syncytial virus infection | |
dc.subject | virology | |
dc.subject | virus pneumonia | |
dc.subject | young adult | |
dc.subject | Adolescent | |
dc.subject | Child | |
dc.subject | Child, Preschool | |
dc.subject | Cross-Sectional Studies | |
dc.subject | Female | |
dc.subject | Hospitalization | |
dc.subject | Humans | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Malaysia | |
dc.subject | Male | |
dc.subject | Odds Ratio | |
dc.subject | Paramyxoviridae Infections | |
dc.subject | Pneumonia, Viral | |
dc.subject | Prevalence | |
dc.subject | Public Health Surveillance | |
dc.subject | Respiratory Syncytial Virus Infections | |
dc.subject | Respiratory Syncytial Virus, Human | |
dc.subject | Risk Factors | |
dc.subject | Young Adult | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1371/journal.pone.0202147 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 13 | |
dc.description.issue | 8 | |
dc.description.page | e0202147 | |
Appears in Collections: | Staff Publications Elements |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1371_journal_pone_0202147.pdf | 594.38 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License