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https://doi.org/10.1371/journal.pone.0201342
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dc.title | Prospective cohort study of corneal endothelial cell loss after Baerveldt glaucoma implantation | |
dc.contributor.author | Iwasaki K. | |
dc.contributor.author | Arimura S. | |
dc.contributor.author | Takihara Y. | |
dc.contributor.author | Takamura Y. | |
dc.contributor.author | Inatani M. | |
dc.date.accessioned | 2019-11-01T08:13:52Z | |
dc.date.available | 2019-11-01T08:13:52Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Iwasaki K., Arimura S., Takihara Y., Takamura Y., Inatani M. (2018). Prospective cohort study of corneal endothelial cell loss after Baerveldt glaucoma implantation. PLoS ONE 13 (7) : e0201342. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0201342 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161221 | |
dc.description.abstract | Purpose To evaluate corneal endothelial cell loss after Baerveldt glaucoma implantation. Methods We prospectively evaluated changes in endothelial cell density (ECD) in the cornea of 59 patients (59 eyes) who underwent Baerveldt glaucoma implantation. Tubes were inserted into the anterior chamber in 45 eyes and pars plana in 14 eyes. The primary outcome measure was the change in corneal ECD after Baerveldt glaucoma implantation. Secondary outcome measures included relationships between corneal ECD and optical coherence tomography images of tube parameters (tube–cornea distance and tube–cornea angle) and prognostic factors for corneal ECD loss. Results Corneal ECD decreased significantly by 9.2% at 12 months after surgery (P = 0.001). In the anterior chamber Baerveldt glaucoma implantation group, corneal ECD at the tube insertion quadrant decreased significantly by 9.6% at 3 months (P = <0.001), 10.7% at 6 months (P = <0.001), and 13.1% at 12 months (P = <0.001). Corneal ECD at the center decreased significantly at 6 months after surgery (7.2% loss; P = 0.012) and at 12 months after surgery (12.1% loss; P = 0.001). Corneal ECD at the contralateral quadrant decreased significantly at 12 months after surgery only (10.3% loss; P = 0.004). In the pars plana Baerveldt glaucoma implantation group, no significant loss of corneal ECD was found in any corneal areas at any post-surgery follow-up visits. Tube-cornea angle was negatively correlated with the rate of corneal ECD loss at the tube insertion quadrant; r = ?0.55 (P = 0.0013). In multivariable analyses, exfoliation glaucoma and narrower tube–cornea angle were significant prognostic factors for severe corneal ECD loss (P = 0.0068 and P = 0.046, respectively). Conclusions Anterior chamber Baerveldt glaucoma implantation causes corneal endothelial cell loss. Corneal endothelial cell loss starts at the tube insertion quadrant. Exfoliation glaucoma and narrower tube-corneal angle are associated with severe loss of corneal endothelial cells. © 2018 Iwasaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20191101 | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | anterior eye chamber | |
dc.subject | Article | |
dc.subject | cohort analysis | |
dc.subject | corneal endothelial cell loss | |
dc.subject | eye surgery | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | human | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | pars plana vitrectomy | |
dc.subject | prognosis | |
dc.subject | pseudoexfoliation | |
dc.subject | risk factor | |
dc.subject | treatment outcome | |
dc.subject | adverse device effect | |
dc.subject | clinical trial | |
dc.subject | complication | |
dc.subject | corneal endothelial cell loss | |
dc.subject | glaucoma | |
dc.subject | glaucoma drainage implant | |
dc.subject | middle aged | |
dc.subject | pathology | |
dc.subject | prospective study | |
dc.subject | very elderly | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Corneal Endothelial Cell Loss | |
dc.subject | Female | |
dc.subject | Glaucoma | |
dc.subject | Glaucoma Drainage Implants | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Prospective Studies | |
dc.subject | Treatment Outcome | |
dc.type | Article | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.1371/journal.pone.0201342 | |
dc.description.sourcetitle | PLoS ONE | |
dc.description.volume | 13 | |
dc.description.issue | 7 | |
dc.description.page | e0201342 | |
Appears in Collections: | Staff Publications Elements |
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