Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms20133272
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dc.titleExtracellular Vesicles in Cardiovascular Diseases: Alternative Biomarker Sources, Therapeutic Agents, and Drug Delivery Carriers
dc.contributor.authorCHONG SUET YEN
dc.contributor.authorLEE CHOON KEONG
dc.contributor.authorHuang, Chenyuan
dc.contributor.authorOu, Yi Hsuan
dc.contributor.authorCHARLES, CHRISTOPHER JOHN
dc.contributor.authorARTHUR MARK RICHARDS
dc.contributor.authorNeupane, Yub Raj
dc.contributor.authorPavon, Maria Vazquez
dc.contributor.authorZHARKOVA, OLGA
dc.contributor.authorPastorin,Giorgia
dc.contributor.authorWANG JIONGWEI
dc.date.accessioned2019-09-23T00:37:17Z
dc.date.available2019-09-23T00:37:17Z
dc.date.issued2019-07-01
dc.identifier.citationCHONG SUET YEN, LEE CHOON KEONG, Huang, Chenyuan, Ou, Yi Hsuan, CHARLES, CHRISTOPHER JOHN, ARTHUR MARK RICHARDS, Neupane, Yub Raj, Pavon, Maria Vazquez, ZHARKOVA, OLGA, Pastorin,Giorgia, WANG JIONGWEI (2019-07-01). Extracellular Vesicles in Cardiovascular Diseases: Alternative Biomarker Sources, Therapeutic Agents, and Drug Delivery Carriers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 (13). ScholarBank@NUS Repository. https://doi.org/10.3390/ijms20133272
dc.identifier.issn1422-0067
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/159426
dc.description.abstract© 2019 by the authors. Licensee MDPI, Basel, Switzerland. T. Cardiovascular diseases (CVD) represent the leading cause of morbidity and mortality globally. The emerging role of extracellular vesicles (EVs) in intercellular communication has stimulated renewed interest in exploring the potential application of EVs as tools for diagnosis, prognosis, and therapy in CVD. The ubiquitous nature of EVs in biological fluids presents a technological advantage compared to current diagnostic tools by virtue of their notable stability. EV contents, such as proteins and microRNAs, represent specific signatures of cellular activation or injury. This feature positions EVs as an alternative source of biomarkers. Furthermore, their intrinsic activity and immunomodulatory properties offer EVs unique opportunities to act as therapeutic agents per se or to serve as drug delivery carriers by acting as miniaturized vehicles incorporating bioactive molecules. In this article, we aim to review the recent advances and applications of EV-based biomarkers and therapeutics. In addition, the potential of EVs as a drug delivery and theranostic platform for CVD will also be discussed.
dc.language.isoen
dc.publisherMDPI
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPhysical Sciences
dc.subjectBiochemistry & Molecular Biology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectextracellular vesicles
dc.subjectcardiovascular disease
dc.subjectbiomarker
dc.subjecttherapeutic
dc.subjectdrug delivery
dc.subjecttheranostics
dc.subjectCELL-DERIVED EXOSOMES
dc.subjectPLURIPOTENT STEM-CELLS
dc.subjectCARDIOMYOCYTE APOPTOSIS
dc.subjectISCHEMIA-REPERFUSION
dc.subjectCARDIAC REGENERATION
dc.subjectINDUCE ANGIOGENESIS
dc.subjectENDOTHELIAL-CELLS
dc.subjectTARGETED DELIVERY
dc.subjectADIPOSE-TISSUE
dc.subjectPROTEIN-LEVELS
dc.typeReview
dc.date.updated2019-09-21T10:26:48Z
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF PHARMACY
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.3390/ijms20133272
dc.description.sourcetitleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.description.volume20
dc.description.issue13
dc.published.statePublished
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