Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/154978
Title: MATHEMATICAL MODELING OF NON-INVASIVE ELECTRICAL IMPEDANCE SPECTROSCOPY OF INTACT HUMAN SKIN
Authors: BETTY TSAI
ORCID iD:   orcid.org/0000-0002-6365-5763
Keywords: mathematical model, electrical impedance, stratum corneum, living epidermis, dermis, analytical solution
Issue Date: 17-Jan-2019
Citation: BETTY TSAI (2019-01-17). MATHEMATICAL MODELING OF NON-INVASIVE ELECTRICAL IMPEDANCE SPECTROSCOPY OF INTACT HUMAN SKIN. ScholarBank@NUS Repository.
Abstract: This dissertation aims to develop and solve mathematical models of electrical impedance spectroscopy (EIS) for intact human skin. In the first part, we develop the analytical framework by developing a mechanistic mathematical model for EIS measurements of human skin, leading to a reduced model and approximate solutions. The reduced model, which only needs to be solved numerically for the viable skin with modified boundary conditions, is verified. Thereafter, a Hankel transform of the reduced model allows for approximate solutions of not only the measured impedance but also the point-wise potential distribution in the skin. Subsequently, an extended generalized model is developed for n skin layers and m electrodes. In the second part on model applications, we determine the in-vivo dielectric properties – resistivity and relative permittivity – of living epidermis and dermis of human skin between 1 kHz and 1 MHz; and demonstrate guidelines for probe design for specific applications.
URI: https://scholarbank.nus.edu.sg/handle/10635/154978
Appears in Collections:Ph.D Theses (Open)

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