Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41390-019-0277-z
DC FieldValue
dc.titleMeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome
dc.contributor.authorCHAN CHANG YIEN
dc.contributor.authorLOURDES PAULA REAL RESONTOC
dc.contributor.authorMd Abdul Qader
dc.contributor.authorCHAN YIONG HUAK
dc.contributor.authorLIU DESHENG, ISAAC
dc.contributor.authorLAU YEW WENG PERRY
dc.contributor.authorMYA THAN
dc.contributor.authorYEO WEE SONG
dc.contributor.authorLOH HWAI LIANG ALWIN
dc.contributor.authorTAN PUAY HOON
dc.contributor.authorWEI CHANGLI
dc.contributor.authorJochen Reiser
dc.contributor.authorSubhra K Biswas
dc.contributor.authorNG KAR HUI
dc.contributor.authorYAP HUI KIM
dc.contributor.editorCynthia, Bearer
dc.date.accessioned2019-03-26T08:01:55Z
dc.date.available2019-03-26T08:01:55Z
dc.date.issued2019-03-01
dc.identifier.citationCHAN CHANG YIEN, LOURDES PAULA REAL RESONTOC, Md Abdul Qader, CHAN YIONG HUAK, LIU DESHENG, ISAAC, LAU YEW WENG PERRY, MYA THAN, YEO WEE SONG, LOH HWAI LIANG ALWIN, TAN PUAY HOON, WEI CHANGLI, Jochen Reiser, Subhra K Biswas, NG KAR HUI, YAP HUI KIM (2019-03-01). MeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome. Pediatric Research 85 (4) : 477-483. ScholarBank@NUS Repository. https://doi.org/10.1038/s41390-019-0277-z
dc.identifier.issn0031-3998
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/152682
dc.description.abstractBACKGROUND: A lack of consensus exists as to the timing of kidney biopsy in children with steroid-dependent nephrotic syndrome (SDNS) where minimal change disease (MCD) predominates. This study aimed at examining the applicability of a biomarker-assisted risk score model to select SDNS patients at high risk of focal segmental glomerulosclerosis (FSGS) for biopsy. METHODS: Fifty-five patients with SDNS and biopsy-proven MCD (n = 40) or FSGS (n = 15) were studied. A risk score model was developed with variables consisting of age, sex, eGFR, suPAR levels and percentage of CD8(+) memory T cells. Following multivariate regression analysis, total risk score was calculated as sum of the products of odds ratios and corresponding variables. Predictive cut-off point was determined using receiver operator characteristics (ROC) curve analysis. RESULTS: Plasma suPAR levels in FSGS patients were significantly higher, while percentage of CD45RO(+)CD8(+)CD3(+) was significantly lower than in MCD patients and controls. ROC analysis suggests the risk score model with threshold score of 16.7 (AUC 0.84, 95% CI 0.72-0.96) was a good predictor of FSGS on biopsy. The 100% PPV cut-off was >24.0, while the 100% NPV was <13.3. CONCLUSION: A suPAR and CD8(+) memory T cell percentage-based risk score model was developed to stratify SDNS patients for biopsy and for predicting FSGS.
dc.description.urihttps://www.nature.com/articles/s41390-019-0277-z
dc.language.isoen
dc.publisherSpringer Nature
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectKidney Biopsy
dc.subjectfocal segmental glomerulosclerosis
dc.subjectminimal change disease
dc.subjectBiomarkers
dc.title.alternativeRisk score model for kidney biopsy
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (MEDICINE)
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1038/s41390-019-0277-z
dc.description.sourcetitlePediatric Research
dc.description.volume85
dc.description.issue4
dc.description.page477-483
dc.published.statePublished
dc.grant.idNMRC/CIRG/1376/2013
dc.grant.idSIgN 10-037
dc.grant.fundingagencyNational Medical Research Council (NMRC)
dc.grant.fundingagencySingapore Immunology Network (SIgN)
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Risk score model AAM.pdf248.19 kBAdobe PDF

OPEN

NoneView/Download
Risk score model AAM tables & figures.pdf381.92 kBAdobe PDF

OPEN

NoneView/Download
MeSsAGe risk score.pdfmain article503.53 kBUnknown

CLOSED

Published

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons