Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-018-05288-0
DC Field | Value | |
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dc.title | Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling | |
dc.contributor.author | Zhao X. | |
dc.contributor.author | Sankaran S. | |
dc.contributor.author | Yap J. | |
dc.contributor.author | Too C.T. | |
dc.contributor.author | Ho Z.Z. | |
dc.contributor.author | Dolton G. | |
dc.contributor.author | Legut M. | |
dc.contributor.author | Ren E.C. | |
dc.contributor.author | Sewell A.K. | |
dc.contributor.author | Bertoletti A. | |
dc.contributor.author | MacAry P.A. | |
dc.contributor.author | Brzostek J. | |
dc.contributor.author | Gascoigne N.R.J. | |
dc.date.accessioned | 2019-03-22T04:30:41Z | |
dc.date.available | 2019-03-22T04:30:41Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Zhao X., Sankaran S., Yap J., Too C.T., Ho Z.Z., Dolton G., Legut M., Ren E.C., Sewell A.K., Bertoletti A., MacAry P.A., Brzostek J., Gascoigne N.R.J. (2018). Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9 (1) : 2716. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-05288-0 | |
dc.identifier.issn | 20411723 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/152565 | |
dc.description.abstract | Foreign antigens are presented by antigen-presenting cells in the presence of abundant endogenous peptides that are nonstimulatory to the T cell. In mouse T cells, endogenous, nonstimulatory peptides have been shown to enhance responses to specific peptide antigens, a phenomenon termed coagonism. However, whether coagonism also occurs in human T cells is unclear, and the molecular mechanism of coagonism is still under debate since CD4 and CD8 coagonism requires different interactions. Here we show that the nonstimulatory, HIV-derived peptide GAG enhances a specific human cytotoxic T lymphocyte response to HBV-derived epitopes presented by HLA-A 02:01. Coagonism in human T cells requires the CD8 coreceptor, but not T-cell receptor (TCR) binding to the nonstimulatory peptide-MHC. Coagonists enhance the phosphorylation and recruitment of several molecules involved in the TCR-proximal signaling pathway, suggesting that coagonists promote T-cell responses to antigenic pMHC by amplifying TCR-proximal signaling. © 2018 The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1038/s41467-018-05288-0 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 9 | |
dc.description.issue | 1 | |
dc.description.page | 2716 | |
dc.published.state | published | |
dc.grant.id | CBRG/0064/2014 | |
dc.grant.id | R571-002-012-592 | |
dc.grant.id | R571-000-272-281 | |
dc.grant.id | NMRC/STaR/013/2012 | |
dc.grant.fundingagency | Singapore Ministry of Health’s National Medical Research Council | |
dc.grant.fundingagency | CREATE | |
dc.grant.fundingagency | National Research Foundation Investigatorship | |
dc.grant.fundingagency | Singapore Translational Research (STaR) | |
Appears in Collections: | Staff Publications Elements |
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