Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-26761-2
Title: Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics
Authors: Han K.
Lang T.
Zhang Z.
Zhang Y.
Sun Y.
Shen Z.
Beuerman R.W. 
Zhou L. 
Min D.
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Han K., Lang T., Zhang Z., Zhang Y., Sun Y., Shen Z., Beuerman R.W., Zhou L., Min D. (2018). Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics. Scientific Reports 8 (1) : 8537. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-26761-2
Abstract: The mechanisms underlying luteolin-induced inhibition of prostate cancer (PCa) stemness have remained elusive. Here, we report that luteolin suppresses PCa stemness through Wnt signaling by upregulation of FZD6 (frizzled class receptor 6). Luteolin inhibits PCa cell proliferation, migration, self-renewal as well as the expression of prostate cancer stem cell markers in vitro. Through iTRAQ-based quantitative proteomics study, we identified 208 differentially expressed proteins in luteolin-treated PC-3 cells. Subsequent mechanistic analysis revealed that luteolin inhibits Wnt signaling by transcriptional upregulation of FZD6, and thereby suppressing the stemness of PCa cells. Furthermore, we identified FZD6 as a tumor suppressor that can abolish PCa stemness. In summary, our findings demonstrate that suppression of Wnt signaling by upregulation of FZD6 is a mechanism underlying luteolin-induced inhibition of PCa stemness. Our work suggests a new therapeutic strategy against human prostate cancer caused by aberrant activation of Wnt signaling. © 2018 The Author(s).
Source Title: Scientific Reports
URI: http://scholarbank.nus.edu.sg/handle/10635/152467
ISSN: 20452322
DOI: 10.1038/s41598-018-26761-2
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