Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bpj.2018.08.029
DC FieldValue
dc.titleActin Dynamics Couples Extracellular Signals to the Mobility and Molecular Stability of Telomeres
dc.contributor.authorJokhun D.S.
dc.contributor.authorShang Y.
dc.contributor.authorShivashankar G.V.
dc.date.accessioned2019-03-08T04:01:36Z
dc.date.available2019-03-08T04:01:36Z
dc.date.issued2018
dc.identifier.citationJokhun D.S., Shang Y., Shivashankar G.V. (2018). Actin Dynamics Couples Extracellular Signals to the Mobility and Molecular Stability of Telomeres. Biophysical Journal 115 (7) : 1166-1179. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bpj.2018.08.029
dc.identifier.issn00063495
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/152084
dc.description.abstractGenome regulatory programs such as telomere functioning require extracellular signals to be transmitted from the microenvironment to the nucleus and chromatin. Although the cytoskeleton has been shown to directly transmit stresses, we show that the intrinsically dynamic nature of the actin cytoskeleton is important in relaying extracellular signals to telomeres. Interestingly, this mechanical pathway not only transmits physical stimuli but also chemical stimuli. The cytoskeletal network continuously reorganizes and applies dynamic forces on the nucleus and feeds into the regulation of telomere dynamics. We further found that distal telomeres are mechanically coupled in a length- and timescale-dependent manner and identified nesprin 2G as well as lamin A/C as being essential to regulate their translational dynamics. Finally, we demonstrated that such mechanotransduction events impinge on the binding dynamics of critical telomere binding proteins. Our results highlight an overarching physical pathway that regulates positional and molecular stability of telomeres. © 2018 Biophysical Society
dc.publisherBiophysical Society
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMECHANOBIOLOGY INSTITUTE
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.1016/j.bpj.2018.08.029
dc.description.sourcetitleBiophysical Journal
dc.description.volume115
dc.description.issue7
dc.description.page1166-1179
dc.published.statepublished
dc.grant.idMOE2012-T3-1-001
dc.grant.fundingagencyMechanobiology Institute, National University of Singapore
dc.grant.fundingagencyMinistry of Education Tier-3 Grant Program
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
j.bpj.2018.08.029.pdf2.45 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

4
checked on Oct 22, 2020

WEB OF SCIENCETM
Citations

2
checked on Jul 17, 2019

Page view(s)

123
checked on Oct 16, 2020

Download(s)

1
checked on Oct 16, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.