Please use this identifier to cite or link to this item: https://doi.org/10.1038/nature24676
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dc.titleIL-11 is a crucial determinant of cardiovascular fibrosis
dc.contributor.authorSchafer S.
dc.contributor.authorViswanathan S.
dc.contributor.authorWidjaja A.A.
dc.contributor.authorLim W.-W.
dc.contributor.authorMoreno-Moral A.
dc.contributor.authorDeLaughter D.M.
dc.contributor.authorNg B.
dc.contributor.authorPatone G.
dc.contributor.authorChow K.
dc.contributor.authorKhin E.
dc.contributor.authorTan J.
dc.contributor.authorChothani S.P.
dc.contributor.authorYe L.
dc.contributor.authorRackham O.J.L.
dc.contributor.authorKo N.S.J.
dc.contributor.authorSahib N.E.
dc.contributor.authorPua C.J.
dc.contributor.authorZhen N.T.G.
dc.contributor.authorXie C.
dc.contributor.authorWang M.
dc.contributor.authorMaatz H.
dc.contributor.authorLim S.
dc.contributor.authorSaar K.
dc.contributor.authorBlachut S.
dc.contributor.authorPetretto E.
dc.contributor.authorSchmidt S.
dc.contributor.authorPutoczki T.
dc.contributor.authorGuimarães-Camboa N.
dc.contributor.authorWakimoto H.
dc.contributor.authorVan Heesch S.
dc.contributor.authorSigmundsson K.
dc.contributor.authorLim S.L.
dc.contributor.authorSoon J.L.
dc.contributor.authorChao V.T.T.
dc.contributor.authorChua Y.L.
dc.contributor.authorTan T.E.
dc.contributor.authorEvans S.M.
dc.contributor.authorLoh Y.J.
dc.contributor.authorJamal M.H.
dc.contributor.authorOng K.K.
dc.contributor.authorChua K.C.
dc.contributor.authorOng B.-H.
dc.contributor.authorChakaramakkil M.J.
dc.contributor.authorSeidman J.G.
dc.contributor.authorSeidman C.E.
dc.contributor.authorHubner N.
dc.contributor.authorSin K.Y.K.
dc.contributor.authorCook S.A.
dc.date.accessioned2019-01-08T09:08:34Z
dc.date.available2019-01-08T09:08:34Z
dc.date.issued2017
dc.identifier.citationSchafer S., Viswanathan S., Widjaja A.A., Lim W.-W., Moreno-Moral A., DeLaughter D.M., Ng B., Patone G., Chow K., Khin E., Tan J., Chothani S.P., Ye L., Rackham O.J.L., Ko N.S.J., Sahib N.E., Pua C.J., Zhen N.T.G., Xie C., Wang M., Maatz H., Lim S., Saar K., Blachut S., Petretto E., Schmidt S., Putoczki T., Guimarães-Camboa N., Wakimoto H., Van Heesch S., Sigmundsson K., Lim S.L., Soon J.L., Chao V.T.T., Chua Y.L., Tan T.E., Evans S.M., Loh Y.J., Jamal M.H., Ong K.K., Chua K.C., Ong B.-H., Chakaramakkil M.J., Seidman J.G., Seidman C.E., Hubner N., Sin K.Y.K., Cook S.A. (2017). IL-11 is a crucial determinant of cardiovascular fibrosis. Nature 552 (7683) : 110-115. ScholarBank@NUS Repository. https://doi.org/10.1038/nature24676
dc.identifier.issn00280836
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/150643
dc.description.abstractFibrosis is a common pathology in cardiovascular disease1. In the heart, fibrosis causes mechanical and electrical dysfunction1,2 and in the kidney, it predicts the onset of renal failure3. Transforming growth factor ?1 (TGF?1) is the principal pro-fibrotic factor4,5, but its inhibition is associated with side effects due to its pleiotropic roles6,7. We hypothesized that downstream effectors of TGF?1 in fibroblasts could be attractive therapeutic targets and lack upstream toxicity. Here we show, using integrated imaging-genomics analyses of primary human fibroblasts, that upregulation of interleukin-11 (IL-11) is the dominant transcriptional response to TGF?1 exposure and required for its pro-fibrotic effect. IL-11 and its receptor (IL11RA) are expressed specifically in fibroblasts, in which they drive non-canonical, ERK-dependent autocrine signalling that is required for fibrogenic protein synthesis. In mice, fibroblast-specific Il11 transgene expression or Il-11 injection causes heart and kidney fibrosis and organ failure, whereas genetic deletion of Il11ra1 protects against disease. Therefore, inhibition of IL-11 prevents fibroblast activation across organs and species in response to a range of important pro-fibrotic stimuli. These results reveal a central role of IL-11 in fibrosis and we propose that inhibition of IL-11 is a potential therapeutic strategy to treat fibrotic diseases. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
dc.publisherNature Publishing Group
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/nature24676
dc.description.sourcetitleNature
dc.description.volume552
dc.description.issue7683
dc.description.page110-115
dc.description.codenNATUA
dc.grant.idNMRC/ STaR/0011/2012
dc.grant.idNCCS
dc.grant.idHHMI
dc.grant.fundingagencyNMRC, National Medical Research Council
dc.grant.fundingagencyNational Cancer Centre of Singapore
dc.grant.fundingagencyHoward Hughes Medical Institute
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