Please use this identifier to cite or link to this item:
Title: Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: A study in ethnic Chinese
Authors: Tan E.-K. 
Tan C.
Fook-Chong S.M.C. 
Lum S.Y.
Chai A.
Chung H.
Shen H.
Zhao Y.
Teoh M.L.
Yih Y.
Pavanni R. 
Chandran V.R.
Wong M.C. 
Keywords: Chinese
Parkinson's disease
Issue Date: 2003
Publisher: Elsevier
Citation: Tan E.-K., Tan C., Fook-Chong S.M.C., Lum S.Y., Chai A., Chung H., Shen H., Zhao Y., Teoh M.L., Yih Y., Pavanni R., Chandran V.R., Wong M.C. (2003). Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: A study in ethnic Chinese. Journal of the Neurological Sciences 216 (1) : 163-167. ScholarBank@NUS Repository.
Abstract: Introduction: Few studies have examined the relationship of coffee and tea in Parkinson's disease (PD). The potential protective effect of coffee intake and risk of PD has not been studied in a Chinese population. There is a high prevalence of caffeine takers among Chinese in our population. Objective: We undertook a case control study to examine the relationship between coffee and tea drinking, cigarette smoking, and other enviromental factors and risk of PD among ethnic Chinese in our population. Methods and Results: 300 PD and 500 population controls were initially screened. Two hundred case control pairs matched for age, gender, and race were finally included in the analysis. Univariate analysis revealed significant association of PD with coffee drinking (p<0.0005), tea drinking (p=0.019), alcohol drinking (p=0.001), cigarette smoking (p<0.0005), and exposure to heavy metals (p=0.006). Conditional logistic regression analysis demonstrated that amount of coffee drunk (OR 0.787, 95%CI 0.664-0.932, p=0.006), amount of tea drunk (OR 0.724, 95%CI 0.559-0.937, p=0.014), number of cigarettes smoked (OR 0.384, 95%CI 0.204-0.722, p=0.003), history of heavy metal and toxin exposure (OR 11.837, 95%CI 1.075-130.366, p=0.044), and heart disease (OR 5.518, 95%CI 1.377-22.116, p=0.016) to be significant factors associated with PD. One unit of coffee and tea (3 cups/day for 10 years) would lead to a 22% and 28% risk reduction of PD. One unit of cigarette smoke (3 packs/day for 10 years) reduced the risk of PD by 62%. Conclusions: We demonstrated a dose-dependent protective effect of PD in coffee and tea drinkers and smokers in an ethnic Chinese population. A history of exposure to heavy metals increased the risk of PD, supporting the multifactorial etiologies of the disease. 2003 Elsevier B.V. All rights reserved.
Source Title: Journal of the Neurological Sciences
ISSN: 0022510X
DOI: 10.1016/j.jns.2003.07.006
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Sep 19, 2019


checked on Dec 31, 2018

Page view(s)

checked on Sep 19, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.