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https://doi.org/10.1002/mds.20246
Title: | Nurr1 mutational screen in Parkinson's disease | Authors: | Tan E.-K. Chung H. Chandran V.R. Tan C. Shen H. Yew K. Pavanni R. Puvan K.-A. Wong M.-C. Teoh M.-L. Yih Y. Zhao Y. |
Keywords: | Mutation Nurr1 Parkinson's disease Polymorphism |
Issue Date: | 2004 | Publisher: | Wiley | Citation: | Tan E.-K., Chung H., Chandran V.R., Tan C., Shen H., Yew K., Pavanni R., Puvan K.-A., Wong M.-C., Teoh M.-L., Yih Y., Zhao Y. (2004). Nurr1 mutational screen in Parkinson's disease. Movement Disorders 19 (12) : 1503-1505. ScholarBank@NUS Repository. https://doi.org/10.1002/mds.20246 | Abstract: | We performed sequence analysis of all the exons and exon-intron boundaries in familial and young-onset Parkinson's disease (PD) in an Asian cohort. None of the patients carried any pathogenic mutations in the Nurr1 gene. We demonstrated a 5 to 10% prevalence of the intron 7 +33 C?T variant among Malay and Indian PD and healthy controls, suggesting that this variant, which was previously described only in 1 Chinese patient, was not a silent mutation but a common polymorphic variant in some ethnic races. 2004 Movement Disorder Society. | Source Title: | Movement Disorders | URI: | http://scholarbank.nus.edu.sg/handle/10635/150235 | ISSN: | 08853185 | DOI: | 10.1002/mds.20246 |
Appears in Collections: | Staff Publications |
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