Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2005.04.103
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dc.titleThe G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients
dc.contributor.authorTan E.K.
dc.contributor.authorShen H.
dc.contributor.authorTan L.C.S.
dc.contributor.authorFarrer M.
dc.contributor.authorYew K.
dc.contributor.authorChua E.
dc.contributor.authorJamora R.D.
dc.contributor.authorPuvan K.
dc.contributor.authorPuong K.Y.
dc.contributor.authorZhao Y.
dc.contributor.authorPavanni R.
dc.contributor.authorWong M.C.
dc.contributor.authorYih Y.
dc.contributor.authorSkipper L.
dc.contributor.authorLiu J.-J.
dc.date.accessioned2018-12-27T06:32:49Z
dc.date.available2018-12-27T06:32:49Z
dc.date.issued2005
dc.identifier.citationTan E.K., Shen H., Tan L.C.S., Farrer M., Yew K., Chua E., Jamora R.D., Puvan K., Puong K.Y., Zhao Y., Pavanni R., Wong M.C., Yih Y., Skipper L., Liu J.-J. (2005). The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients. Neuroscience Letters 384 (3) : 327-329. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2005.04.103
dc.identifier.issn03043940
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/150233
dc.description.abstractA common heterozygous leucine-rich repeat kinase 2 (LRRK2) mutation 6055G > A transition (G2019S) accounts for about 3-7% of familial Parkinson's disease (PD) and 1-1.6% sporadic PD in a number of European populations. To determine the prevalence of the G1019S mutation in our Asian population, we conducted genetic analysis of this mutation in 1000 PD and healthy controls. The G2019S mutation was not detected in any of our study subjects. The prevalence of G2019S mutation is rare (<0.1%) in our population, suggesting that occurrence of this mutation may vary amongst different ethnic races. This has important clinical implication when implementing guidelines for genetic testing. 2005 Elsevier Ireland Ltd. All rights reserved.
dc.publisherElsevier
dc.sourceScopus
dc.subjectLRRK2
dc.subjectMutation
dc.subjectParkinson's disease
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.neulet.2005.04.103
dc.description.sourcetitleNeuroscience Letters
dc.description.volume384
dc.description.issue3
dc.description.page327-329
dc.grant.idNMRC
dc.grant.fundingagencyNational Medical Research Council
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