Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00439-005-0038-4
Title: Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: Clinical association
Authors: Tan E.K. 
Puong K.Y.
Chan D.K.Y.
Yew K.
Fook-Chong S. 
Shen H.
Ng P.W.
Woo J.
Yuen Y. 
Pavanni R. 
Wong M.C. 
Puvan K. 
Zhao Y.
Issue Date: 2005
Publisher: Springer Verlag
Citation: Tan E.K., Puong K.Y., Chan D.K.Y., Yew K., Fook-Chong S., Shen H., Ng P.W., Woo J., Yuen Y., Pavanni R., Wong M.C., Puvan K., Zhao Y. (2005). Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: Clinical association. Human Genetics 118 (3-4) : 484-488. ScholarBank@NUS Repository. https://doi.org/10.1007/s00439-005-0038-4
Abstract: We provided data to show that the transcriptional activity of wildtype - 258T in the parkin promoter region was significantly higher than the - 258G variant in human cell lines. The transcriptional activity of wildtype -258T was significantly increased under oxidative stress by hydrogen peroxide, but this was not observed for the - 258G variant. The transcriptional upregulation was significantly higher for wildtype -258T compared to -258G variant at 0.1, 0.2 and 0.4 mM of hydrogen peroxide. Similar results were obtained when the cells were treated with a proteasome inhibitor, MG132. Furthermore, in a case control study involving 753 subjects, we demonstrated that the parkin promoter -258G variant was associated with an increased risk of sporadic Parkinson's disease (PD) in the elderly ethnic Chinese population. Our clinical and laboratory data provide corroborative evidence that some older individuals who have the -258G variant may have a higher risk of developing PD. Springer-Verlag 2005.
Source Title: Human Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/150229
ISSN: 03406717
DOI: 10.1007/s00439-005-0038-4
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