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|Title:||Isolation of a novel protein tyrosine phosphatase inhibitor, 2-methyl-fervenulone, and its precursors from Streptomyces||Authors:||Wang H.
Kah Leong Lim
Su Ling Yeo
Mui Mui Sim
|Issue Date:||2000||Publisher:||American Chemical Society||Citation:||Wang H., Kah Leong Lim, Su Ling Yeo, Xu X., Mui Mui Sim, Ting A.E., Wang Y., Yee S., Tan Y.H., Pallen C.J. (2000). Isolation of a novel protein tyrosine phosphatase inhibitor, 2-methyl-fervenulone, and its precursors from Streptomyces. Journal of Natural Products 63 (12) : 1641-1646. ScholarBank@NUS Repository. https://doi.org/10.1021/np000293+||Abstract:||High-throughput screening identified an extract from Streptomyces sp. IM 2096 with inhibitory activity toward several protein tyrosine phosphatases (PTPs). Four 1,2,4-triazine compounds 2096A-D (1-4) were isolated from this extract and their structures elucidated by interpretation of spectroscopic data and confirmed by degradation and synthesis. The novel glycocyamidine derivatives 1 and 2 are diastereomers and may interconvert. Both are inactive in the PTP inhibition assay. Compounds 1 and 2 are unstable and partially decompose to 3 and glycocyamidine (5) at room temperature. Compound 3, known as MSD-92 or 2-methyl-fervenulone, is a broad-specificity PTP inhibitor with comparable potency to vanadate. The imidazo[4,5-e]-1,2,4-triazine (4), inactive in the PTP-inhibition assay, may be a degradation product of 3.||Source Title:||Journal of Natural Products||URI:||http://scholarbank.nus.edu.sg/handle/10635/150207||ISSN:||1633864||DOI:||10.1021/np000293+|
|Appears in Collections:||Staff Publications|
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