Please use this identifier to cite or link to this item: https://doi.org/10.1021/np000293+
Title: Isolation of a novel protein tyrosine phosphatase inhibitor, 2-methyl-fervenulone, and its precursors from Streptomyces
Authors: Wang H. 
Kah Leong Lim 
Su Ling Yeo 
Xu X.
Mui Mui Sim 
Ting A.E. 
Wang Y. 
Yee S.
Tan Y.H.
Pallen C.J. 
Issue Date: 2000
Publisher: American Chemical Society
Citation: Wang H., Kah Leong Lim, Su Ling Yeo, Xu X., Mui Mui Sim, Ting A.E., Wang Y., Yee S., Tan Y.H., Pallen C.J. (2000). Isolation of a novel protein tyrosine phosphatase inhibitor, 2-methyl-fervenulone, and its precursors from Streptomyces. Journal of Natural Products 63 (12) : 1641-1646. ScholarBank@NUS Repository. https://doi.org/10.1021/np000293+
Abstract: High-throughput screening identified an extract from Streptomyces sp. IM 2096 with inhibitory activity toward several protein tyrosine phosphatases (PTPs). Four 1,2,4-triazine compounds 2096A-D (1-4) were isolated from this extract and their structures elucidated by interpretation of spectroscopic data and confirmed by degradation and synthesis. The novel glycocyamidine derivatives 1 and 2 are diastereomers and may interconvert. Both are inactive in the PTP inhibition assay. Compounds 1 and 2 are unstable and partially decompose to 3 and glycocyamidine (5) at room temperature. Compound 3, known as MSD-92 or 2-methyl-fervenulone, is a broad-specificity PTP inhibitor with comparable potency to vanadate. The imidazo[4,5-e]-1,2,4-triazine (4), inactive in the PTP-inhibition assay, may be a degradation product of 3.
Source Title: Journal of Natural Products
URI: http://scholarbank.nus.edu.sg/handle/10635/150207
ISSN: 1633864
DOI: 10.1021/np000293+
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