Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2009.11.021
Title: A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
Authors: Krüger R.
Sharma M.
Riess O.
Gasser T.
Van Broeckhoven C.
Theuns J.
Aasly J.
Annesi G.
Bentivoglio A.R.
Brice A.
Djarmati A.
Elbaz A.
Farrer M.
Ferrarese C.
Gibson J.M.
Hadjigeorgiou G.M.
Hattori N.
Ioannidis J.P.A.
Jasinska-Myga B.
Klein C.
Lambert J.-C.
Lesage S.
Lin J.-J.
Lynch T.
Mellick G.D.
de Nigris F.
Opala G.
Prigione A.
Quattrone A.
Ross O.A.
Satake W.
Silburn P.A.
Tan E.K. 
Toda T.
Tomiyama H.
Wirdefeldt K.
Wszolek Z.
Xiromerisiou G.
Maraganore D.M.
Keywords: Genetics
HtrA2
Omi
PARK13
Parkinson's disease
Issue Date: 2011
Publisher: Elsevier
Citation: Krüger R., Sharma M., Riess O., Gasser T., Van Broeckhoven C., Theuns J., Aasly J., Annesi G., Bentivoglio A.R., Brice A., Djarmati A., Elbaz A., Farrer M., Ferrarese C., Gibson J.M., Hadjigeorgiou G.M., Hattori N., Ioannidis J.P.A., Jasinska-Myga B., Klein C., Lambert J.-C., Lesage S., Lin J.-J., Lynch T., Mellick G.D., de Nigris F., Opala G., Prigione A., Quattrone A., Ross O.A., Satake W., Silburn P.A., Tan E.K., Toda T., Tomiyama H., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Maraganore D.M. (2011). A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Neurobiology of Aging 32 (3) : 548.e9-548.e18. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2009.11.021
Abstract: High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common Omi/HtrA2 variants in the Genetic Epidemiology of Parkinson's disease (GEO-PD) consortium.GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the Omi/HtrA2 gene in approximately 2-3. kb intervals (rs10779958, rs2231250, rs72470544, rs1183739, rs2241028). Fixed as well as random effect models were used to provide summary risk estimates of Omi/HtrA2 variants.The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five Omi/HtrA2 SNPs and PD were observed using either fixed effect or random effect models. The summary odds ratios ranged between 0.98 and 1.08 and the estimates of between-study heterogeneity were not large (non-significant Q statistics for all 5 SNPs; I2 estimates 0-28%). Trends for association were seen for participants of Scandinavian descent for rs2241028 (OR 1.41, p=0.04) and for rs1183739 for age at examination (cut-off 65 years; OR 1.17, p=0.02), but these would not be significant after adjusting for multiple comparisons and their Bayes factors were only modest.This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide. © 2009 Elsevier Inc.
Source Title: Neurobiology of Aging
URI: http://scholarbank.nus.edu.sg/handle/10635/150143
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2009.11.021
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
j.neurobiolaging.2009.11.021.pdf322.7 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

39
checked on Jun 18, 2019

WEB OF SCIENCETM
Citations

25
checked on Dec 31, 2018

Page view(s)

23
checked on Jun 20, 2019

Download(s)

2
checked on Jun 20, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.