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Title: Botulinum toxin improves quality of life in hemifacial spasm: Validation of a questionnaire (HFS-30)
Authors: Tan E.-K. 
Fook-Chong S. 
Lum S.-Y.
Lim E. 
Keywords: Botulinum toxin
Hemifacial spasm
Quality of life
Issue Date: 2004
Citation: Tan E.-K., Fook-Chong S., Lum S.-Y., Lim E. (2004). Botulinum toxin improves quality of life in hemifacial spasm: Validation of a questionnaire (HFS-30). Journal of the Neurological Sciences 219 (1-Feb) : 151-155. ScholarBank@NUS Repository.
Abstract: Background: Hemifacial spasm (HFS) can be disabling and affect quality of life. There is a lack of a validated scale for evaluating botulinum toxin (BTX) response in HFS. Objective: We examined the validity and reliability of a self-rating health-related quality of life (HRQOL) questionnaire (HFS-30) in HFS and investigated the correlation of this questionnaire with the neurologists' assessment of severity of HFS and response to botulinum toxin (BTX) treatment. Methods: HFS patients were asked to answer a total of 30 self-rating questions divided into seven subscales: Mobility; Activities of Daily Living (ADL); Emotional Well-being; Stigma; Social support; Cognition; and Communication. All of the items were scored on a 5-point scales ranging from 0 ("never") to 4 ("always"). They were also asked to assess their response to the BTX treatment based on a similar questionnaire at 6-8 weeks after BTX. The validity, reliability and sensitivity of the questionnaire were analyzed statistically. Results: There were 80 HFS patients with mean age of 56.3±11.1 (S.D.) years (range 35 to 81), consisting of 54 (67.5%) females, 26 (32.5%) males. The intraclass correlation coefficient (ICC) and Cronbach's ? were more than 0.7 for the majority of the items and subscales, respectively. There was a good positive correlation of severity of HFS with the subscale scores. Regression analysis of physicians' assessment of response to BTX on change in scores from baseline as rated by patients demonstrated a significant correlation. Conclusions: We demonstrated validity, reliability and sensitivity of the HFS-30 questionnaire. BTX improves quality of life in HFS. © 2004 Elsevier B.V. All rights reserved.
Source Title: Journal of the Neurological Sciences
ISSN: 0022510X
DOI: 10.1016/j.jns.2004.01.010
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