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Title: Structural connectome alterations in prodromal and de novo Parkinson's disease patients
Authors: Wen M.-C. 
Heng H.S.E.
Hsu J.-L.
Xu Z.
Liew G.M.
Au W.L. 
Chan L.L.
Tan L.C.S. 
Tan E.K. 
Keywords: Neuroimaging
Olfactory impairment
Parkinson's disease
Prodromal phase
White matter
Issue Date: 2017
Publisher: Elsevier Ltd
Citation: Wen M.-C., Heng H.S.E., Hsu J.-L., Xu Z., Liew G.M., Au W.L., Chan L.L., Tan L.C.S., Tan E.K. (2017). Structural connectome alterations in prodromal and de novo Parkinson's disease patients. Parkinsonism and Related Disorders 45 : 21-27. ScholarBank@NUS Repository.
Abstract: Background Although the clinical signs of prodromal Parkinson's disease (PD) have been identified, little is known about the neural features of the prodromal phase of PD (proPD). The aim of this study was to examine the structural network alterations from healthy aging to proPD and to early PD. Methods 181 non-demented and non-depressed participants comprising 55 healthy controls (HCs), 20 proPDs, and 106 de novo PD patients (dPDs) were included in the study and underwent clinical assessment and diffusion tensor imaging scanning. Graph-theoretical analysis and network-based statistics, with age and gender as nuisance covariates, were used. Results Compared with HCs and dPDs, proPD patients showed significantly elevated small-worldness and clustering coefficient (Ps < 0.01) and greater local connectivity between regions relating to motor, olfactory and sleep functions (Ps < 0.05). Although dPDs and HCs did not differ on all graph-theoretic metrics, dPD patients showed decreased connectivity within the prefrontal regions and between the left temporal and occipital lobes (P < 0.05). The connectivity strength between these regions significantly distinguished between diagnostic groups. Connectivity between bilateral SMAs was correlated with UPSIT in HCs and with UPDRS-III in dPDs. Connectivity between the right SMA and putamen was correlated RBDSQ in proPDs. Conclusions Increased network efficiency and connectivity of proPDs and decreased local connectivity of dPDs might suggest the emergence and dissipation of neural compensation in the prodromal phase and in early PD, respectively. Nonetheless, longitudinal studies are needed to follow up the long-term structural network changes of proPD patients. � 2017 Elsevier Ltd
Source Title: Parkinsonism and Related Disorders
ISSN: 13538020
DOI: 10.1016/j.parkreldis.2017.09.019
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