Please use this identifier to cite or link to this item: https://doi.org/10.1111/ene.13803
Title: Non-motor symptoms in early Parkinson's disease with different motor subtypes and their associations with quality of life
Authors: Huang X.
Ng S.Y.-E.
Chia N.S.-Y.
Setiawan F.
Tay K.-Y. 
Au W.-L. 
Tan E.-K. 
Tan L.C.-S. 
Keywords: early Parkinson's disease
fatigue
motor subtypes
non-motor symptoms
postural instability/gait difficulty
sleep impairment
tremor-dominant
Issue Date: 2018
Publisher: Blackwell Publishing Ltd
Citation: Huang X., Ng S.Y.-E., Chia N.S.-Y., Setiawan F., Tay K.-Y., Au W.-L., Tan E.-K., Tan L.C.-S. (2018). Non-motor symptoms in early Parkinson's disease with different motor subtypes and their associations with quality of life. European Journal of Neurology. ScholarBank@NUS Repository. https://doi.org/10.1111/ene.13803
Abstract: Background and purpose: The aim of this study was to examine non-motor symptoms in different Parkinson's disease (PD) motor subtypes and their associations with quality of life (QoL). Methods: A total of 132 patients with early PD with comprehensive motor examinations and non-motor symptom assessments were included. Motor subtypes were classified based on Stebbins� method. Non-motor symptoms were assessed by the Non-Motor Symptom Scale (NMSS) and validated by more comprehensive instruments, including the Pittsburgh Sleep Quality Index (PSQI) and Fatigue Severity Scale (FSS). QoL was measured by the Parkinson's Disease Questionnaire-8. Results: We identified 66 patients (50%) with tremor-dominant (TD) subtype, 47 (35.6%) with postural instability and gait disorder (PIGD) subtype and 19 (14.4%) with Intermediate subtype. By comparing NMSS scores, patients with the PIGD subtype had more severe sleep impairment and fatigue (domain 2 score: 5.64 vs. 2.52, P < 0.001), urinary symptoms (domain 7 score: 6.96 vs. 3.48, P = 0.005) and overall more severe non-motor symptoms (NMSS total score: 25.89 vs. 17.27, P = 0.031), compared with patients with the TD subtype. Validation using the PSQI and FSS again suggested that patients with the PIGD subtype had independently and significantly more severe sleep impairment (PSQI score: 5.57 vs. 4.29, P = 0.020) and fatigue (FSS score: 34.81 vs. 25.85, P = 0.003) compared with patients with the TD subtype. Several non-motor symptoms had significant associations with QoL, among which sleep impairment and fatigue (P < 0.0001, partial r2 = 0.273) explained the largest proportion of QoL variability in patients with PD. Conclusions: Patients with the PIGD subtype had more severe sleep impairment, fatigue and urinary disturbance compared with patients with the TD subtype. Sleep impairment and fatigue were the most important factors affecting QoL independent of motor subtypes. Prompt identification and treatment of these non-motor symptoms may improve patients� QoL. � 2018 EAN
Source Title: European Journal of Neurology
URI: http://scholarbank.nus.edu.sg/handle/10635/148985
ISSN: 13515101
DOI: 10.1111/ene.13803
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