Please use this identifier to cite or link to this item: https://doi.org/10.1177/1545968317753075
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dc.titleDifferential White Matter Regional Alterations in Motor Subtypes of Early Drug-Naive Parkinson�s Disease Patients
dc.contributor.authorWen M.-C.
dc.contributor.authorHeng H.S.E.
dc.contributor.authorLu Z.
dc.contributor.authorXu Z.
dc.contributor.authorChan L.L.
dc.contributor.authorTan E.K.
dc.contributor.authorTan L.C.S.
dc.date.accessioned2018-11-23T06:37:13Z
dc.date.available2018-11-23T06:37:13Z
dc.date.issued2018
dc.identifier.citationWen M.-C., Heng H.S.E., Lu Z., Xu Z., Chan L.L., Tan E.K., Tan L.C.S. (2018). Differential White Matter Regional Alterations in Motor Subtypes of Early Drug-Naive Parkinson�s Disease Patients. Neurorehabilitation and Neural Repair 32 (2) : 129-141. ScholarBank@NUS Repository. https://doi.org/10.1177/1545968317753075
dc.identifier.issn15459683
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/148932
dc.description.abstractBackground. Parkinson�s disease (PD) can be classified into tremor dominant (TD) and postural instability and gait difficulty (PIGD) subtypes with TD considered as the benign subtype. The neural alterations of the 2 subtypes in the early stages before administration of medications remain elusive. Objective. This study assessed the subtype-related white matter (WM) microstructural features in newly diagnosed and drug-naive PD patients from the Parkinson�s Progression Markers Initiative (PPMI). Methods. Sixty-five early PDs with stable subtypes (52 TD and 13 PIGD patients) and 61 controls underwent diffusion tensor imaging (DTI) scanning and clinical assessment. Tract-based special statistics (TBSS), graph-theoretical and network-based analyses were used to compare WM regional and network features between groups. Results. No differences in disease stages and duration were found between the 2 patient groups. TD patients showed increased fractional anisotropy (FA), but decreased radial and axial diffusivities (RD and AD) in several projection, association, and commissural tracts, compared with PIGD patients and controls. Motor severity had mild-to-moderate correlations with FA and RD of the corpus callosum (genu) in TD, but strong correlations with FA and RD of multiple association tracts in PIGD. Conversely, no significant network changes were noted. Conclusions. TD patients showed regionally increased FA but decreased diffusivities, implying neural reorganization to compensate PD pathology in early stages. PIGD patients, despite having similar disease stages and duration, exhibited more WM degradation. These results demonstrate differential WM regional features between the 2 subtypes in early PD and support the notion of TD being a benign subtype. � 2018, � The Author(s) 2018.
dc.publisherSAGE Publications Inc.
dc.subjectdiffusivity
dc.subjectfractional anisotropy
dc.subjectParkinson�s Progression Markers Initiative
dc.subjectpostural instability and gait difficulty
dc.subjecttremor
dc.subjectwhite matter
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1177/1545968317753075
dc.description.sourcetitleNeurorehabilitation and Neural Repair
dc.description.volume32
dc.description.issue2
dc.description.page129-141
dc.published.statepublished
dc.grant.idNMRC/CNIG/1160/2016
dc.grant.fundingagencyUCB
dc.grant.fundingagencyPfizer
dc.grant.fundingagencyBMS, Bristol-Myers Squibb
dc.grant.fundingagencyMJFF, Michael J. Fox Foundation for Parkinson's Research
dc.grant.fundingagencyBiogen Idec
dc.grant.fundingagencyGE Healthcare
dc.grant.fundingagencyRoche
dc.grant.fundingagencyLundbeckfonden
dc.grant.fundingagencyEli Lilly and Company
dc.grant.fundingagencyMerck
dc.grant.fundingagencyGenentech
dc.grant.fundingagencyTCR12dec010
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