Please use this identifier to cite or link to this item: https://doi.org/10.1017/S0954579417001262
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dc.titleCumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression
dc.contributor.authorSilveira P.P.
dc.contributor.authorPokhvisneva I.
dc.contributor.authorParent C.
dc.contributor.authorCai Shirong
dc.contributor.authorRema A.S.S.
dc.contributor.authorBROEKMAN BIRIT FROUKJE PHILIPP
dc.contributor.authorRifkin-Graboi A.
dc.contributor.authorPluess M.
dc.contributor.authorO'Donnell K.J.
dc.contributor.authorMICHAEL JOSEPH MEANEY
dc.date.accessioned2018-04-05T10:08:38Z
dc.date.available2018-04-05T10:08:38Z
dc.date.issued2017-11-22
dc.identifier.citationSilveira P.P., Pokhvisneva I., Parent C., Cai Shirong, Rema A.S.S., BROEKMAN BIRIT FROUKJE PHILIPP, Rifkin-Graboi A., Pluess M., O'Donnell K.J., MICHAEL JOSEPH MEANEY (2017-11-22). Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development and Psychopathology 29 (5) : 1601-1617. ScholarBank@NUS Repository. https://doi.org/10.1017/S0954579417001262
dc.identifier.issn09545794
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/139806
dc.description.abstractWhile many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene. Prenatal adversities were computed in two community birth cohorts using information on health during pregnancy, birth weight, gestational age, income, domestic violence/sexual abuse, marital strain, as well as maternal smoking, anxiety, and depression. A genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. Prenatal adversities predicted a wide range of developmental and behavioral alterations in children as young as 2 years of age in both cohorts. There were interactions between the genetic score and adversities for several domains of the Child Behavior Checklist (CBCL), with pervasive developmental problems remaining significant adjustment for multiple comparisons. Scores combining different prenatal adverse exposures predict childhood behavior and interact with the genetic background to influence the risk for psychopathology. Copyright © Cambridge University Press 2017.
dc.publisherCambridge University Press
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDEPT OF PSYCHOLOGICAL MEDICINE
dc.description.doi10.1017/S0954579417001262
dc.description.sourcetitleDevelopment and Psychopathology
dc.description.volume29
dc.description.issue5
dc.description.page1601-1617
dc.description.codenDPESB
dc.identifier.isiut000425952800006
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
dc.published.statePublished
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.fundingagencyNational Medical Research Council
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